2024, Асафова, В. Д., Кулаков, С. А., Быркин, В. А., Бортникова, С. А. , Белогорлов, А. А., Быркин, Виктор Александрович, Асафова, Валерия Денисовна, Белогорлов, Антон Анатольевич, Кулаков, Сергей Алексеевич, Бортникова, Светлана Алексеевна

Изучение процессов взаимодействия нанопористого материала с несмачивающей жидкостью вызывает интерес не только с точки зрения фундаментальной науки в части распространения жидкости в наноканалах (нанофлюидика), но и как применение таких систем для поглощения энергии удара, взрыва и вибраций. Именно для этих приложений особенно важно знать механизм распространения жидкости в нанопористых материалах и делать оценки временных характеристик отклика системы на высокоскоростные импульсные воздействия. Целью данной работы являлось исследование влияния скорости изменения давления в системе на процесс заполнения пор нанопористого материала несмачивающей жидкостью. Проведена серия экспериментов заполнения – вытекания в системе нанопористый материал (гидрофобизированный нанопористый силикагель Fluka 100 C8 (60759-50G) производства Sigma-Aldrich) – несмачивающая жидкость (деионизированная дистиллированная вода) при скоростях изменения внутреннего объема 0.24÷11.78 10‒2 см3/с при температуре 20 °С. На основе экспериментальных данных разработана методика определения скорости заполнения нанопористого материала несмачивающей жидкостью. Разработанная методика будет в дальнейшем использоваться для изучения заполнения нанопористых материалов несмачивающими жидкостями.

2024, Bortnikova, S.A., Belogorlov, A.A., Бортникова, Светлана Алексеевна, Белогорлов, Антон Анатольевич

2024, Asafova, V.D., Kulakov, S.A., Bortnikova, S.A., Belogorlov, A.A., Асафова, Валерия Денисовна, Кулаков, Сергей Алексеевич, Бортникова, Светлана Алексеевна, Белогорлов, Антон Анатольевич

2020, Bortnikova, S. A., Belogorlov, A. A., Borman, V. D., Бортникова, Светлана Алексеевна, Белогорлов, Антон Анатольевич

© 2020 Published under licence by IOP Publishing Ltd.It is known that for the most nanoporous medium-non-wetting liquid systems are observed non-outflow phenomenon. It is shown that this phenomenon may depend on many factors, one of which is a waiting time. The observed anomalously slow relaxation (non-wetting liquid outflow) caused by formation of strongly interacting states of liquid clusters in pores. Previously was shown that relaxation of such states can occur due to relaxation of metastable local configurations of filled and empty pores. In the present work the relaxation of non-wetting liquid (water) dispersed in disordered nanoporous medium (hydrophobic silica gel Libersorb 23) for 6 and 9° C is considered. The pore size distribution functions of captured liquid for 9° C are obtained. Some local configurations for 6 and 9° C are analyzed and their lifetimes are defined.

2021, Akopdzhanov, A. G., Shimanovsky, N. L., Belogorlov, A. A., Bortnikova, S. A., Белогорлов, Антон Анатольевич, Бортникова, Светлана Алексеевна

© 2021, Springer Science+Business Media, LLC, part of Springer Nature.The possibilities of using porous silicon nanostructured containers as drug carriers are considered. The main design principles of the nanocontainers and the possibility of using pore surface modification to achieve the optimal regimes of drug loading and controlled in vivo drug release are formulated. Results from studies devoted to the application of porous silica containers are presented. The main prospects and research tasks in this field are related to reducing the object size, increasing the biocompatibility, increasing the drug loading volume, and achieving the optimal drug release kinetics.

2024, Asafova, V.D., Kulakov, S.A., Bortnikova, S.A., Belogorlov, A.A., Асафова, Валерия Денисовна, Кулаков, Сергей Алексеевич, Бортникова, Светлана Алексеевна, Белогорлов, Антон Анатольевич

2025, Akopdzhanov, A. G., Pavlik, T. I., Bortnikova, S. A., Belogorlov,A.A., Бортникова, Светлана Алексеевна, Белогорлов, Антон Анатольевич

2021, Mingalev, P. G., Bortnikova, S. A., Belogorlov, A. A., Бортникова, Светлана Алексеевна, Белогорлов, Антон Анатольевич

© 2021, Pleiades Publishing, Ltd.This work presents the results of studying hydrophobized silica gel Fluka 100 C8 + C1 with additional chemical surface modification by single-link alkylsilane. The material is studied by low-temperature nitrogen sorption and liquid porometry, including additional liquid porometry methods. The results of studying the system without additional modification are also presented. All results are presented for three temperatures: 20, 40, and 60°C. It is shown that additional chemical modification allows an increase in the fraction of the nonwetting liquid flowing from the pores with increasing temperature while maintaining a significant proportion of nonwetting liquid that has not outflowed under normal conditions. The obtained results show that, by additional modification, it is possible to control the process of the time relaxation of a nonwetting liquid in a nanoporous medium.

2021, Shimanovsky, N. L., Belogorlov, A. A., Khrebtov, D. S., Bortnikova, S. A., Белогорлов, Антон Анатольевич, Бортникова, Светлана Алексеевна

© 2021, Springer Science+Business Media, LLC, part of Springer Nature.The outflow kinetics of aqueous solutions of n-propanol as model liquids (drug solutions) from hydrophobic nanoporous silica gel 60 C8 was studied. The solution surface tension was shown to influence the hysteresis of intrusion-extrusion pressures and outflow rate. The use of substances changing the surface tension of the injected solution, in particular doxorubicin, allows one to control the relaxation/release of doxorubicin molecules in/from the focus of the disorder at the optimum rate. The obtained results can be used to create drug delivery systems based on silicon nanoparticles.

2020, Belogorlov, A. A., Borman, V. D., Bortnikova, S. A., Byrkin, V. A., Tronin, I. V., Tronin, V. N., Белогорлов, Антон Анатольевич, Бортникова, Светлана Алексеевна, Быркин, Виктор Александрович, Тронин, Иван Владимирович

© 2020 Published under licence by IOP Publishing Ltd.In the present paper we present the results of experimental and theoretical studies of intrusion-extrusion and relaxation of non-wetting liquid in three Fluka porous media. New data on hysteresis of intrusion-extrusion and dependence of the degree of filling of a porous body on time in the process of extrusion were obtained experimentally. It has been established that in all the conducted experiments the liquid extrusion took place in two stages: at the first stage of fast relaxation the characteristic time of outflow is several seconds, at the second stage of slow relaxation the characteristic time is several hundred seconds. The experimental data obtained are described in the theoretical model [1]. For the studied porous media, the existence at the initial moment of time of local states with short leakage times (a few seconds or less) and states with large leakage times (hundreds of seconds) was established. Porous bodies in which the coexistence of fast and slow states at the initial moment of time is established are investigated for the first time.