Персона:
Савельева, Татьяна Александровна

Научные группы

Научная группа

Организационные подразделения

Организационная единица

Инженерно-физический институт биомедицины

Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.

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Савельева

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Татьяна Александровна

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Теперь показываю 1 - 10 из 36

Только метаданные
Optimization of energy parameters for laser-induced PDT of cervical tissues using numerical simulation and fluorescent monitoring
(2023) Alekseeva, P. M.; Efendiev, K. T.; Savelieva, T. A.; Loschenov, V. B.; Эфендиев, Канамат Темботович; Савельева, Татьяна Александровна; Лощенов, Виктор Борисович
Только метаданные
Intraoperative control of hemoglobin oxygen saturation in the intestinal wall during anastomosis surgery
(2021) Kustov, D. M.; Kharnas, S. S.; Levkin, V. V.; Gorbunov, A. S.; Savelieva, T. A.; Mironov, T. A.; Loschenov, V. B.; Савельева, Татьяна Александровна; Лощенов, Виктор Борисович
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.During surgery for colon cancer, monitoring of the oxygen saturation of hemoglobin in the tissues under study makes it possible to assess the degree of blood supply to the anastomosis areas of the colon. Adequate blood supply in this area is decisive in terms of the consistency of the anastomosis and can significantly reduce the risk leakage of anastomosis. In this work, we propose a new approach to assessing the hemoglobin oxygen saturation based on measuring both the diffuse reflectance and transmittance spectra of the colon wall tissues. The proposed method is based on the use of two fiber-optic tools for irradiation from both sides—the intestinal lumen and the outside of the intestinal wall. The spectra are recorded from the external side. To determine the degree of hemoglobin saturation, two algorithms, both based on the Taylor series expansion of the coefficient of light attenuation by tissues, are proposed. The results of a clinical study of the proposed approach on volunteers were obtained, allowing to draw a conclusion about the applicability of the approach in a clinical setting.
Только метаданные
Intraoperative assessment of blood flow during esophageal resection using fluorescence diagnostics and diffuse scattering spectroscopy
(2024) Krivetskaya, A. A.; Kustov, D. M.; Savelieva, T. A.; Loschenov, V. B.; Кривецкая, Анна Александровна; Савельева, Татьяна Александровна; Лощенов, Виктор Борисович
Только метаданные
Evaluation of tissue blood supply during esophagectomy using fluorescent diagnostics and diffuse scattering spectroscopy in visible region
(2024) Krivetskaya, A. A.; Kustov, D. M.; Savelieva, T. A.; Loschenov, V. B.; Кривецкая, Анна Александровна; Савельева, Татьяна Александровна; Лощенов, Виктор Борисович
The success of the surgical treatment of a tumor or obstruction of the esophagus with subsequent anastomosis application depends on the level of blood supply to the stitched tissues. Intraoperative assessment of blood flow is widely used in medicine and can be used as a diagnostic method that affects the outcome of surgery and reduces the frequency of postoperative complications for the patient. In this work, the assessment of blood supply during esophageal resection operations was carried out using two techniques sequentially: fluorescent diagnostics with indocyanine green and measurement of hemoglobin oxygen saturation by diffuse scattering spectroscopy in the visible wavelength range. The first method was used to assess the integrity of the vascular network structure in the area of anastomosis and blood flow through the sutured tissues, the second one вЂ“ for local assessment of hemoglobin oxygen saturation in the investigated area. Conducted clinical study involved the participation of nine patients with malignant neoplasms (six cases) or esophageal obstruction (three cases). The presence of postoperative complications was compared with the measurement results. Anastomosis failure was observed in only one patient. According to the results of the study, with the use of the investigated method of assessing blood supply, there is a tendency towards a decrease in the frequency of anastomosis leaks (11.1 % compared with 21.4 %). Therefore, fluorescent diagnostics with indocyanine green and measurement of hemoglobin oxygen saturation using diffuse scattering spectroscopy were affirmed as methods that allow increasing the safety of surgical procedures by assessing the risk of postoperative complications, including anastomosis failures.
Только метаданные
STUdy OF ENERGy TRANSFER pROCESSES BETWEEN RARE EARTh IONS ANd phOTOSENSITIZER mOLECULES FOR phOTOdyNAmIC ThERApy WITh IR-EXCITATION ИССЛЕдОвАНИЕ пРОЦЕССОв пЕРЕдАчИ ЭНЕРГИИ мЕЖдУ РЕдКОЗЕмЕЛЬНЫмИ ИОНАмИ И мОЛЕКУЛАмИ фОТОСЕНСИБИЛИЗАТОРОв дЛя ЗАдАч фОТОдИНАмИчЕСКОи ТЕРАпИИ С вОЗБУЖдЕНИЕм в ИК-дИАпАЗОНЕ
(2021) Proydakova, V. Y.; Romanishkin, I. D.; Kuznetsov, S. V.; Lukyanets, E. A.; Pominova, D. V.; Bogatova, A. S.; Akhlyustina, E. V.; Saveleva, T. A.; Loschenov, V. B.; Поминова, Дарья Вячеславовна; Ахлюстина, Екатерина Витальевна; Савельева, Татьяна Александровна; Лощенов, Виктор Борисович
© 2021 Russian Photodynamic Association. All rights reserved.Today, photodynamic therapy is one of the most promising minimally invasive methods of treatment of various diseases, including cancer. The main limitation of this method is the insufficient penetration into the tissue of laser radiation used to activate photosensitizer molecules,which makes it difficult to carry out therapy in the treatment of large or deep-seated tumors. In this regard, there is a great interest in thedevelopment of new strategies for photodynamic therapy using infrared radiation for excitation, the wavelengths of which fall into the “transparencywindow” of biological tissues. In this work, it was proposed to use upconversion NaGdF4:Yb:Er nanoparticles (UCNP), which absorbinfrared excitation and serve as a donor that transfers energy to the photosensitizer. Photosens and phthalosens were chosen as the mostpromising photosensitizers for the study. The aim of this work was to study the energy transfer processes between upconversion nanoparticlesdoped with rare-earth ions and photosensitizer molecules. in order to excite photosensitizers with IR radiation and carry out photodynamictherapy of deep-seated neoplasms. Using spectroscopic and time-resolved methods, it has been demonstrated that there is an efficientenergy transfer between upconversion particles and photosensitizers phthalosens and photosens. The calculated efficiency of energy transferby the Foerster mechanism was 41% for the UCNP + photosens system and 69% for the UCNP + phthalosens system. It has been experimentallyand theoretically proved that there is a binding of photosensitizer molecules with UCNP by means of surfactants, leading to a reductionin the distance between them, due to which effective nonradiative energy transfer is realized. The generation of singlet oxygen by the phthalosensphotosensitizer upon excitation by means of energy transfer from UCNP, excited at 980 nm wavelength of, has been demonstrated.
Только метаданные
Method for Assessing the Optical Properties of Multilayer Tissues of the Gastrointestinal Tract ex Vivo
(2024) Krivetskaya, A. A.; Savelieva, T. A.; Kustov, D. M.; Loschenov, V. B.; Кривецкая, Анна Александровна; Савельева, Татьяна Александровна; Лощенов, Виктор Борисович
Только метаданные
Multimodal method of tissue differentiation in neurooncology using Raman spectroscopy, fluorescence and diffuse reflectance spectroscopy
(2022) Romanishkin, I. D.; Ospanov, A.; Savelyeva, T. A.; Loschenov, V. B.; Савельева, Татьяна Александровна; Лощенов, Виктор Борисович; Оспанов, Ануар
Только метаданные
Fast Spectroscopic Technique of Optical Biopsy of Intracranial Tumors
(2024) Romanishkin, I. D.; Ospanov A.; Savelieva, T. A.; Shugai, S. V.; Loschenov, V. B.; Савельева, Татьяна Александровна; Лощенов, Виктор Борисович; Оспанов, Ануар
Только метаданные
Method for rapid intraoperative analysis of the optical properties of multilayered walls of hollow organs
(2024) Savelieva, T. A.; Krivetskaya, A. A.; Levkin, V. V.; Loschenov, V. B.; Савельева, Татьяна Александровна; Кривецкая, Анна Александровна; Лощенов, Виктор Борисович
Только метаданные
Combined spectroscopic and video fluorescent instrument for intraoperative navigation when removing a glial tumor
(2020) Loshchenov, M. V.; Borodkin, A. V.; Linkov, K. G.; Kosyrkova, A. V.; Savelieva, T. A.; Loschenov, V. B.; Савельева, Татьяна Александровна; Лощенов, Виктор Борисович
© 2020 SPIE.The new approach to intraoperative navigation during glial brain tumors removal is presented. A combined method is proposed for simultaneous spectroscopic and video fluorescence analysis of the state of tissues in the destruction zone using the applied part performed in the form of a neurosurgical aspirator cannula. In the walls of the applied part there are tubular channels into which lighting and receiving optical fibers are integrated. At the end of the cannula, the channels for optical fibers are arranged so as to perform spectroscopic analysis in contact with the surface of the biological tissue, as well as video fluorescence analysis at the working distance to the surface of the tissue. The joint use of fiber-optic systems for recording the video stream and spectral dependences allows real-time assessment of the degree of pathological tissue changes in the field of view of the video system, which are also located in the aspiration zone, with the simultaneous quantification of diagnostically significant spectroscopic criteria. System testing was carried out on samples of human intracranial tumors obtained during neurosurgical operations. During the removal of a tumor from different sites (tumor center, perifocal area), the degree of in vivo fluorescence signal from the tumor site was determined intraoperatively using a Zeiss Opmi Pentero intraoperative microscope in Blue 400 mode. From the selected area of the tumor, biopsy material was taken (presumably homogeneous in its properties) with subsequent measurement of spectra and combined images using the developed device. A high correlation was shown between the level of the fluorescence signal recorded spectroscopically and the brightness of the fluorescence image in the endoscopic channel of the device. The level of the fluorescent signal showed a high correlation with the degree of malignancy of tissues according to the results of pathomorphological examination.