Персона: Эпштейн, Наталья Борисовна
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Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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Наталья Борисовна
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- ПубликацияТолько метаданныеQuasistatic hysteresis loops of magnetic nanoparticles in a rotating magnetic field(2020) Usov, N. A.; Gubanova, E. M.; Epstein, N. B.; Belyaeva, G. A.; Oleinikov, V. A.; Усов, Николай Александрович; Губанова, Елизавета Михайловна; Эпштейн, Наталья Борисовна; Олейников, Владимир Александрович© 2019Quasistatic hysteresis loops of a single-domain magnetic nanoparticle with uniaxial anisotropy in a rotating magnetic field have been calculated. Magnetic hysteresis is shown to exist only in a limited range of reduced magnetic field amplitudes, 0.5 < h0 < 1, where h0 = H0/Ha, H0 is the amplitude of the rotating magnetic field, Ha being the particle anisotropy field. An analytical formula is obtained for the particle coercive force as a function of the reduced field amplitude. In the domain h0 < 0.5 the magnetization reversal of a particle is impossible, since the final energy barrier exists between the potential wells of the particle for all orientations of applied magnetic field. On the other hand, in the domain h0 > 1 the total energy of the nanoparticle has a single energy minimum, so that there is no magnetic hysteresis. Quasistatic hysteresis loops of a randomly oriented assembly of non interacting nanoparticles in a rotating magnetic field are also obtained.
- ПубликацияТолько метаданныеSyntheses of Melanotan II and YSL Amide by Ajiphase® Methodology(2019) Sanguliya, T. A.; Antipova, A. O.; Shkavrov, S. V.; Epstein, N. B.; Шкавров, Сергей Владимирович; Эпштейн, Наталья Борисовна© 2019, Springer Science+Business Media, LLC, part of Springer Nature.The promising antitumor peptides Melanotan II and YSL amide were synthesized for the first time in gram quantities in overall yields of 72 and 50%, respectively, by Ajiphase® methodology. This method was shown to be promising for peptide manufacturing. The proposed methods are as convenient as polymer-phase syntheses with the reagent consumption and associated analytical simplicity of classical solution syntheses.
- ПубликацияТолько метаданные68Ga-adsorption on the Si-nanoparticles(2019) Skrabkova, H. S.; Bubenschikov, V. B.; Kodina, G. E.; Lunev, A. S.; Epshtein, N. B.; Эпштейн, Наталья Борисовна© Published under licence by IOP Publishing Ltd.In recent years, more and more attention has been paid to nanoparticles (NPs) as target drug delivery systems. Silicon-based nanoparticles are one of the most biocompatible nanomaterials that have become widespread. In this research, we studied the possibility of gallium-68 sorption on silicon (Si-SiOx) and silicon dioxide (SiO2) nanoparticles without their surface modification. Conditions allowing to obtain 68Ga-NPs with radiochemical yield ≥ 90% were found. 68Ga-SiO2 showed much higher stability over 68Ga-Si-SiOx in both in vitro and in vivo experiments.