Publication: 68Ga-adsorption on the Si-nanoparticles
Дата
2019
Авторы
Skrabkova, H. S.
Bubenschikov, V. B.
Kodina, G. E.
Lunev, A. S.
Epshtein, N. B.
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© Published under licence by IOP Publishing Ltd.In recent years, more and more attention has been paid to nanoparticles (NPs) as target drug delivery systems. Silicon-based nanoparticles are one of the most biocompatible nanomaterials that have become widespread. In this research, we studied the possibility of gallium-68 sorption on silicon (Si-SiOx) and silicon dioxide (SiO2) nanoparticles without their surface modification. Conditions allowing to obtain 68Ga-NPs with radiochemical yield ≥ 90% were found. 68Ga-SiO2 showed much higher stability over 68Ga-Si-SiOx in both in vitro and in vivo experiments.
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68Ga-adsorption on the Si-nanoparticles / Skrabkova, H.S. [et al.] // IOP Conference Series: Materials Science and Engineering. - 2019. - 487. - № 1. - 10.1088/1757-899X/487/1/012026