Персона:
Калягина, Нина Анатольевна

Организационные подразделения

Организационная единица

Инженерно-физический институт биомедицины

Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.

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Калягина

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Нина Анатольевна

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Теперь показываю 1 - 10 из 17

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Optical biopsy: Fundamentals and applications in neurosurgery
(2021) Romanishkin, I. D.; Maklygina, Yu. S.; Borodkin, A. V.; Tsarukaev, B. A.; Savelieva, T. A.; Grachev, P. V.; Kalyagina, N. A.; Orlov, A. V.; Loschenov, V. B.; Савельева, Татьяна Александровна; Калягина, Нина Анатольевна; Лощенов, Виктор Борисович
© 2021 Institute of Physics Publishing. All rights reserved.Currently, there is a significant increase in the incidence of cancer of the central nervous system. Determination of the boundaries of intracerebral and intramedullary tumors is especially difficult. The urgency of the problem of determining the boundaries of astrocytic tumors is due to the peculiarities of their growth along myelinated nerve fibers and vessels, leading to the infiltration of healthy white matter by tumor cells, which affects the high frequency of postoperative relapses. The complexity of surgery for intramedullary tumors of the spinal cord is that the tumor does not always have a clear border and the risk of injury is high due to the smaller size of the operated area compared to the brain. Reliable information regarding the volume of the resected tumor should be obtained by intraoperative imaging. The solution to this problem is implemented mainly in three directions: the use of intraoperative computed tomography, magnetic resonance imaging and ultrasound scanning, and various combinations of these methods. Unfortunately, all these methods of intraoperative diagnostics do not allow real-time examination of tissues in an operating wound and/or do not provide a simultaneous analysis of both structural and metabolic changes. The limitations of intraoperative navigation methods in neurosurgery have led to the relevance of the development of an accurate spectroscopic method for in vivo determination of the content of specific metabolic markers and structural changes accompanying the development of the tumor process in the nervous tissue. Various approaches to intraoperative navigation based on optical spectroscopy are called optical biopsy. In this article, we present the methods and tools developed in recent years for spectroscopic guidance in neurooncology. First of all, this, of course, concerns the analysis of spectral dependences recorded before, during and after tumor removal. We have used such modalities of optical spectroscopy as fluorescence, diffuse reflectance spectroscopy and spontaneous Raman scattering. An equally important issue on the way to increasing the efficiency of tumor resection is the development of new instrumentation; therefore, we have developed a number of new devices, which are a combination of well-known neurosurgical instruments and laser and fiber-optic technologies. Last but not least is the issue of rapid classification of the studied tissues based on the recorded signals, which was solved by us using machine learning methods.
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Intraoperative video-fluorescence navigation by PpIX and tissue saturation measurement during surgical resection of gastric malignant tumor
(2022) Kustov, D. M.; Yakovlev, D. V.; Moskalev, A. S.; Kozlikina, E. I.; Loshchenov, M. V.; Kalyagina, N. A.; Loschenov, V. B.; Лощенов, Максим Викторович; Калягина, Нина Анатольевна; Лощенов, Виктор Борисович
Fluorescence visualization of pathologies is a popular form of endoscopic diagnostics in medicine. Interest in fluorescence optical visualization consists in providing information on the fluorescent signal spatial distribution by the photosensitizer fluorescence, which has a selective accumulation in tumor. Together with this, the determination of tissue saturation makes possible to assess the adequate of blood supply to anastomosis during surgical operation. © 2022 IEEE.
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Effective Fluorescence Control for TUR of the Bladder
(2022) Loshchenov, M.; Kalyagina, N.; Yagudaev, D.; Borodkin, A.; Kozlikina, E.; Kustov, D.; Amouroux, M.; Daul, C.; Moskalev, A.; Blondel, W.; Калягина, Нина Анатольевна; Бородкин, Александр Викторович
We present here the effective video-fluorescence diagnosis with laser excitation at 635 nm with subsequent TUR of the bladder. After the diagnosis, the main tumor foci were resected first, and then a fluorescence analysis of the tumor borders was performed. Small fluorescing tumor tissues, not seen by cystoscopy in white light, were detected and the diagnostic fluorescence contrast was measured to quantify 5-ALA in tissues. The endoscopic images, registering the tumors, are very important in the development of signal processing techniques in augmented reality mode or mosaic mapping of the obtained series of images. © 2022 IEEE.
Только метаданные
3D bladder models for fluorescence imaging on bimodal system
(2022) Kozlikina, E.; Kalyagina, N.; Loshchenov, M.; Efendiev, K.; Borodkin, A.; Калягина, Нина Анатольевна; Лощенов, Максим Викторович; Эфендиев, Канамат Темботович; Бородкин, Александр Викторович
Только метаданные
Cost-effective device for locating and circumscribing superficial tumors with contrast enhancement and fluorescence quantification
(2024) Udeneev, A. M.; Kalyagina, N. A.; Efendiev, K. T.; Febenchukova, A. A.; Kulichenko, A. M.; Loshchenov, M. V.; Калягина, Нина Анатольевна; Эфендиев, Канамат Темботович; Лощенов, Максим Викторович
Two Bispectral contrast enhancement approaches for the fluorescence diagnosis with chlorine-e6 and a wide field-of-view imaging system with fluorescence excitation at 405 nm and time-resolved background suppression were analyzed and compared. Two techniques for the contrast enhancement of a fluorescent video system (Red/Green (R/G) ratio and Red-Green (R-G)) with time-resolved background suppression for fluorescent diagnosis (FD) were tested in four patients with basal cell carcinoma (BCC). The results of both contrast enhancement methods were compared for the diagnostic efficiency for FD of BCC. Both techniques successfully determined the boundaries of the lesions and the fluorescence intensity. Both contrast enhancement modes have proven effective in identifying tumor borders in cases of low contrast in BCC FD with Ce6. While the Red/Green (R/G) mode provides sharper lesion borders, the Red minus Green (R-G) mode visualizes more fluorescent features and makes it easier to assess the lesion margins.
Только метаданные
Comparison of chlorin-e6 detection efficiency by video systems with excitation wavelengths of 405nm and 635nm
(2023) Udeneev, A.; Kulichenko, A.; Kalyagina, N.; Plotnikova, A.; Loshchenov, M.; Калягина, Нина Анатольевна; Лощенов, Максим Викторович
Только метаданные
Comparison of Ce6 photobleaching rate on the surface and in the depth of basalioma during photodynamic therapy at a wavelength of 660 nm using registration of fluorescence excited in the red and violet ranges
(2024) Udeneev, A. M.; Febenchukova, A. A.; Kalyagina, N. A.; Калягина, Нина Анатольевна
Только метаданные
Dual channel video platform for fluorescence diagnostics in augmented reality
(2024) Loshchenov, M. V.; Udeneev, A. M.; Kalyagina, N. A.; Лощенов, Максим Викторович; Калягина, Нина Анатольевна
Только метаданные
Spectroscopic Verification of Contrast Enhancement Methods in Fluorescence Diagnostics of Basal Cell Carcinoma with Scar Tissue
(2024) Febenchukova, A. A.; Udeneev, A. M.; Kulichenko, A. M.; Kalyagina, N. A.; Efendiev, K. T.; Loschenov, V. B.; Калягина, Нина Анатольевна; Эфендиев, Канамат Темботович; Лощенов, Виктор Борисович; Уденеев, Андрей Михайлович
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COMPARISON OF OPTICAL-SPECTRAL CHARACTERISTICS OF GLIOBLASTOMA AT INTRAOPERATIVE DIAGNOSIS AND EX VIVO OPTICAL BIOPSY СРАВНЕНИЕ ОПТИКО-СПЕКТРАЛЬНЫХ ХАРАКТЕРИСТИК ГЛИОБЛАСТОМЫ ПРИ ИНТРАОПЕРАЦИОННОИ ДИАГНОСТИКЕ И ОПТИЧЕСКОИ БИОПСИИ EX VIVO
(2024) Romanishkin, I. D.; Savelieva, T. A.; Ospanov, A.; Kalyagina, N. A.; Krivetskaya, A. A.; Udeneev, A. M.; Loschenov, V. B.; Савельева, Татьяна Александровна; Оспанов, Ануар; Калягина, Нина Анатольевна; Кривецкая, Анна Александровна; Уденеев, Андрей Михайлович; Лощенов, Виктор Борисович