Персона: Кривецкая, Анна Александровна
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Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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Анна Александровна
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- ПубликацияТолько метаданныеMethod for rapid intraoperative analysis of the optical properties of multilayered walls of hollow organs(2024) Savelieva, T. A.; Krivetskaya, A. A.; Levkin, V. V.; Loschenov, V. B.; Савельева, Татьяна Александровна; Кривецкая, Анна Александровна; Лощенов, Виктор Борисович
- ПубликацияТолько метаданныеOptical Spectral Approach to Breast Tissue Oxygen Saturation Analysis for Mastectomy Perioperative Control(2022) Kustov, D. M.; Krivetskaya, A. A.; Savelieva, T. A.; Loschenov, V. B.; Кривецкая, Анна Александровна; Савельева, Татьяна Александровна; Лощенов, Виктор БорисовичThe purpose of our research is to study the ability of the developed method of hemoglobin detection, based on the fiber-optic spectral analysis in visible region, to determine the level of blood supply to breast tissues before surgical treatment, intraoperatively and during observation of the patient in the postoperative period, when breast tissue is healing. The significant effect of subcutaneous adipose tissue on the shape of diffuse reflectance spectra due to scattering leads to a decrease in the accuracy of determining hemoglobin oxygen saturation and hemoglobin concentration from them. The variability of the subcutaneous adipose tissue layer is quite high, which also leads to a high variability of the spectra within a class of tissues that are in the same physiological state, which implies that the intraclass variability due to this factor should be assessed for a specific problem, not considering it random. For this purpose, in our work, we constructed optical phantoms simulating various thicknesses of the subcutaneous adipose tissue in order to determine the effect of its light scattering on the diffuse reflectance spectrum and to select the optimal configuration of optical fibers. © 2022 by the authors.
- ПубликацияТолько метаданныеSpectroscopic Saturation Assessment for Different Organs of the Gastrointestinal Tract(2024) Krivetskaya, A.; Kustov, D.; Levkin, V.; Savelieva, T.; Loschenov, V.; Кривецкая, Анна Александровна; Савельева, Татьяна Александровна; Лощенов, Виктор Борисович
- ПубликацияТолько метаданныеIntraoperative assessment of blood flow during esophageal resection using fluorescence diagnostics and diffuse scattering spectroscopy(2024) Krivetskaya, A. A.; Kustov, D. M.; Savelieva, T. A.; Loschenov, V. B.; Кривецкая, Анна Александровна; Савельева, Татьяна Александровна; Лощенов, Виктор Борисович
- ПубликацияТолько метаданныеEvaluation of tissue blood supply during esophagectomy using fluorescent diagnostics and diffuse scattering spectroscopy in visible region(2024) Krivetskaya, A. A.; Kustov, D. M.; Savelieva, T. A.; Loschenov, V. B.; Кривецкая, Анна Александровна; Савельева, Татьяна Александровна; Лощенов, Виктор БорисовичThe success of the surgical treatment of a tumor or obstruction of the esophagus with subsequent anastomosis application depends on the level of blood supply to the stitched tissues. Intraoperative assessment of blood flow is widely used in medicine and can be used as a diagnostic method that affects the outcome of surgery and reduces the frequency of postoperative complications for the patient. In this work, the assessment of blood supply during esophageal resection operations was carried out using two techniques sequentially: fluorescent diagnostics with indocyanine green and measurement of hemoglobin oxygen saturation by diffuse scattering spectroscopy in the visible wavelength range. The first method was used to assess the integrity of the vascular network structure in the area of anastomosis and blood flow through the sutured tissues, the second one – for local assessment of hemoglobin oxygen saturation in the investigated area. Conducted clinical study involved the participation of nine patients with malignant neoplasms (six cases) or esophageal obstruction (three cases). The presence of postoperative complications was compared with the measurement results. Anastomosis failure was observed in only one patient. According to the results of the study, with the use of the investigated method of assessing blood supply, there is a tendency towards a decrease in the frequency of anastomosis leaks (11.1 % compared with 21.4 %). Therefore, fluorescent diagnostics with indocyanine green and measurement of hemoglobin oxygen saturation using diffuse scattering spectroscopy were affirmed as methods that allow increasing the safety of surgical procedures by assessing the risk of postoperative complications, including anastomosis failures.