Персона: Лощенов, Виктор Борисович
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Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
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- ПубликацияОткрытый доступPhotodynamic Therapy under Diagnostic Control of Wounds with Antibiotic-Resistant Microflora(2024) Shiryaev, A.; Kalyagina, N.; Ivankov, M.; Efendiev, K.; Loschenov, V.; Калягина, Нина Анатольевна; Эфендиев, Канамат Темботович; Лощенов, Виктор БорисовичBackground: Difficulties in the treatment of purulent wounds are caused by bacterial biofilms, which results in decontamination limitations. Infected wounds are not sufficiently susceptible to existing antibiotics, necessitating the search for alternative approaches to reduce the concentration of pathogenic microflora. Methods: This study describes an approach to the effective treatment of wounds by photodynamic inactivation or therapy (PDI/PDT) of antibiotic-resistant microflora under fluorescence control. For this purpose, laser and LED light (660ў??680 nm) and different groups of photosensitizers (PS) (1% solutions of methylene blue, aluminum phthalocyanine, chlorine e6 and nanocomposites containing these groups of PS) were used. The study included 90 patients with various wounds. Some patients were subjected to fluorescence diagnosis by laser spectral analysis before the PDT. Results: Positive results were achieved in 76 patients (84%, p andlt; 0.05). After the first PDT session, a decrease in the concentration of microflora was noticeable. By the third and seventh days, a significant to complete inactivation of bacteria was obtained. In all patients who were photo-diagnosed before PDT, a significant PS concentration decrease of more than 75% after PDT was obtained. Conclusion: PDT is an effective method for the inactivation of antibiotic-resistant pathogens, including in long non-healing wounds, contributing also to early tissue regeneration.
- ПубликацияОткрытый доступPolycationic Photosensitizers as Effective Anticancer Agents That Destroy Cancer Stem Cells, Cancer Vascularization and Induce Protective Desmoplastic Reaction around Lung Cancers(2024) Kogan, E.; Meerovich, G.; Karshieva, S.; Akhlyustina, E.; Loschenov, V.; Меерович, Геннадий Александрович; Ахлюстина, Екатерина Витальевна; Лощенов, Виктор БорисовичPDT using PSs based on polycationic derivatives of synthetic bacteriochlorin against Lewis lung carcinoma provides effective inhibition of tumor growth with an increase in the lifespan and survival of mice in the group. PDT with polycationic photosensitizers destroys CSCs and tumor neovascularization, and activates the desmoplastic reaction. These results open up new opportunities for increasing the effectiveness of treatment and reducing the incidence of relapses and metastases after PDT.
- ПубликацияТолько метаданныеОn the aggregation of polycationic photosensitizer upon binding to Gram-negative bacteria(2024) Romanishkin, I. D.; Akhlyustina, E. V.; Meerovich, G. A.; Loschenov, V. B.; Strakhovskaya, M.G.; Ахлюстина, Екатерина Витальевна; Меерович, Геннадий Александрович; Лощенов, Виктор Борисович
- ПубликацияТолько метаданныеTumor fluorescence and oxygenation monitoring during photodynamic therapy with chlorin e6 photosensitizer(2024) Efendiev, K.; Alekseeva, P.; Linkov, K.; Loschenov, V.; Эфендиев, Канамат Темботович; Лощенов, Виктор БорисовичThe study is aimed at developing a method for monitoring photodynamic therapy (PDT) of a tumor using chlorin-type photosensitizers (PSs). Lack of monitoring of chlorin e6 (Cђ?6) photobleaching, hemoglobin oxygenation and blood flow during light exposure can limit the PDT effectiveness. Phototheranostics includes spectral-fluorescence diagnostics of Ce6 distribution in the NIR range and PDT with simultaneous assessment of hemoglobin oxygenation and tumor blood flow. Fluorescence diagnostics and PDT were performed using the single laser Ћ?exc=660‚?5 nm. Combined spectroscopic PDT monitoring method allowed simultaneous estimation of Ce6 photobleaching, hemoglobin oxygenation and tumor vascular thrombosis during PDT without interrupting the therapeutic light exposure. The developed method of tumor phototheranostics using chlorin-type PSs makes it possible to personalize the duration of therapeutic light exposure during PDT.
- ПубликацияТолько метаданныеPhotodynamic therapy of lung cancer with photosensitizers based on polycationic derivatives of synthetic bacteriochlorin (experimental study)(2023) Kogan, E. A.; Meerovich, G. A.; Karshieva, S. Sh.; Akhlyustina, E. V.; Loschenov, V. B.; Меерович, Геннадий Александрович; Ахлюстина, Екатерина Витальевна; Лощенов, Виктор Борисович
- ПубликацияТолько метаданныеPhotodynamic inactivation of bacteria: Why it is not enough to excite a photosensitizer(2023) Meerovich, G. A.; Akhlyustina, E. V.; Romanishkin, I. D.; Loschenov, V. B.; Меерович, Геннадий Александрович; Ахлюстина, Екатерина Витальевна; Лощенов, Виктор Борисович
- ПубликацияТолько метаданныеSPECTROSCOPIC STUDY OF METHYLENE BLUE IN VIVO: EFFECTS ON TISSUE OXYGENATION AND TUMOR METABOLISM СПЕКТРОСКОПИЧЕСКОЕ ИССЛЕДОВАНИЕ МЕТИЛЕНОВОГО СИНЕГО IN VIVO: ВЛИЯНИЕ НА ОКСИГЕНАЦИЮ ТКАНЕИ И ОПУХОЛЕВЫИ МЕТАБОЛИЗМ(2023) Pominova, D. V.; Ryabova, A. V.; Skobeltsin, A. S.; Markova, I. V.; Loschenov, V. B.; Поминова, Дарья Вячеславовна; Рябова, Анастасия Владимировна; Лощенов, Виктор Борисович
- ПубликацияТолько метаданныеNear-infrared phototheranostics of tumors with protoporphyrin IX and chlorin e6 photosensitizers(2023) Efendiev, K.; Alekseeva, P.; Shiryaev, A.; Loschenov, V.; Эфендиев, Канамат Темботович; Лощенов, Виктор Борисович