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Фроня, Анастасия Андреевна

Организационные подразделения

Организационная единица

Инженерно-физический институт биомедицины

Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.

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Фроня

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Анастасия Андреевна

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Теперь показываю 1 - 10 из 19

Только метаданные
Experimental Study of Laser Plasma of Low-Density Volume-Structured Targets
(2019) Borisenko, N. G.; Sahakyan, A. T.; Puzyrev, V. N.; Starodub, A. N.; Fronya, A. A.; Фроня, Анастасия Андреевна
© 2019, Pleiades Publishing, Ltd.The results of a laser—matter interaction experiment are presented in the paper. Low-density volume-structured material (cellulose triacetate) is used as a target in the experiments. Low-density materials are of interest for both fundamental and applied research. The information on how the parameters of the target and laser radiation influence the penetration of laser radiation through the generated plasma layer is generalized. The energy, spatial, spectral, and temporal characteristics of the plasma of low-density cellulose triacetate targets are analyzed.
Только метаданные
Morphology and photoluminescence properties of silicon nanoparticles deposited in helium-nitrogen mixtures maintained at low residual pressures
(2021) Fronya, A. A.; Antonenko, S. V.; Derzhavin, S. I.; Karpov, N. V.; Kharin, A. Yu.; Garmash, A. A.; Kargin, N. I.; Klimentov, S. M.; Timoshenko, V. Yu.; Kabashin, A. V.; Фроня, Анастасия Андреевна; Антоненко, Сергей Васильевич; Гармаш, Александр Александрович; Каргин, Николай Иванович; Климентов, Сергей Михайлович; Тимошенко, Виктор Юрьевич; Кабашин, Андрей Викторович
We elaborated a technique of pulsed laser ablation in gas mixtures (He-N2), maintained under residual pressures of 0.5-5 Torr to deposit silicon (Si)-based nanostructured films on a substrate. We show that the deposited films can exhibit strong photoluminescence (PL) emission with the position of peaks depending on the pressure of ambient gas and the ratio of gases in the mixture. Nanostructured films prepared in pure He gas exhibited a strong band in the infrared range (around 760 nm) and a weak band in the green range (550 nm), which were attributed to quantum-confined excitonic states in small Si nanocrystals and radiative transitions via the localized electronic states in silicon suboxide coating, respectively. In contrast, nanostructured films prepared in He-N2 mixtures exhibited more intense “green-yellow” PL band centered at 580 nm, which was attributed to a radiative recombination in amorphous oxynitride (a-SiNxOy) coating of Si nanocrystals. We also present a detailed analysis of morphology of nanostructures Si-based films prepared by laser ablation. Finally, we show that the nanocrystals can be removed from the substrate and milled by ultrasound to form aqueous solutions of colloidal Si nanopartiles. The fabricated Si-based nanocrystals present a promising object for theranostics, combining imaging functionality based on PL emission and a series of therapy functionalities (photo and radiofrequency hyperthermia, photodynamic therapy). © 2021 Institute of Physics Publishing. All rights reserved.
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EXPERIMENTAL INVESTIGATION OF THE EFFECT OF UVA RADIATION ON THE CORONAVIRUS INFECTIVE PROPERTIES
(2021) Guschin, V. A.; Nikiforova, M. A.; Siniavin, A. E.; Russu, L. I.; Zavestovskaya, I. N.; Fronya, A. A.; Grigoryeva, M. S.; Завестовская, Ирина Николаевна; Фроня, Анастасия Андреевна; Григорьева, Мария Сергеевна
© 2021, Allerton Press, Inc.Abstract: The results of experimental studies of the effect of ultraviolet radiation in the UVA wavelength range safe for humans on the β-coronavirus infective properties are presented. Bovine coronavirus not pathogenic for humans is selected as a prototype of the COVID-19 (SARS-CoV-2) pathogenic agent. LEDs with wavelengths of 371 nm and 401 nm are used as a radiation source. It is shown that a dose-dependent decrease in the virus infectious titer is observed for both UVA wavelengths.
Только метаданные
Features of the Second Harmonic Generation in CTA Target Plasma
(2019) Fronya, A. A.; Sahakyan, A. T.; Puzyrev, V. N.; Starodub, A. N.; Фроня, Анастасия Андреевна
The results of experiments on the study of the second harmonic generation in plasma of low-density cellulose triacetate targets are presented. Targets were irradiated using a neodymium glass laser at the nanosecond fundamental frequency. The data on the time sweep of the second harmonic generated in plasma are obtained. The features of the spectral and time distributions of the second harmonic radiation are discovered: with increasing the density, a maximum appears in the spectrum, and two maxima appear in the time dependence of the intensity.
Только метаданные
Germanium Nanoparticles Prepared by Laser Ablation in Low Pressure Helium and Nitrogen Atmosphere for Biophotonic Applications
(2022) Fronya, A. A.; Antonenko, S. V.; Karpov, N. V.; Pokryshkin, N. S.; Eremina, A. S.; Kharin, A. Y.; Dombrovska, Y. I.; Garmash, A. A.; Kargin, N. I.; Klimentov, S. M.; Timoshenko, V. Y.; Фроня, Анастасия Андреевна; Антоненко, Сергей Васильевич; Еремина, Анна Сергеевна; Гармаш, Александр Александрович; Каргин, Николай Иванович; Климентов, Сергей Михайлович; Тимошенко, Виктор Юрьевич
Due to particular physico-chemical characteristics and prominent optical properties, nanostructured germanium (Ge) appears as a promising material for biomedical applications, but its use in biological systems has been limited so far due to the difficulty of preparation of Ge nanostructures in a pure, uncontaminated state. Here, we explored the fabrication of Ge nanoparticles (NPs) using methods of pulsed laser ablation in ambient gas (He or He-N2 mixtures) maintained at low residual pressures (1-5 Torr). We show that the ablated material can be deposited on a substrate (silicon wafer in our case) to form a nanostructured thin film, which can then be ground in ethanol by ultrasound to form a stable suspension of Ge NPs. It was found that these formed NPs have a wide size dispersion, with sizes between a few nm and hundreds of nm, while a subsequent centrifugation step renders possible the selection of one or another NP size fraction. Structural characterization of NPs showed that they are composed of aggregations of Ge crystals, covered by an oxide shell. Solutions of the prepared NPs exhibited largely dominating photoluminescence (PL) around 450 nm, attributed to defects in the germanium oxide shell, while a separated fraction of relatively small (5-10 nm) NPs exhibited a red-shifted PL band around 725 nm under 633 nm excitation, which could be attributed to quantum confinement effects. It was also found that the formed NPs exhibit high absorption in the visible and near-IR spectral ranges and can be strongly heated under photoexcitation in the region of relative tissue transparency, which opens access to phototherapy functionality. Combining imaging and therapy functionalities in the biological transparency window, laser-synthesized Ge NPs present a novel promising object for cancer theranostics.
Только метаданные
Laser-Ablation Synthesis of Colloidal ZrN Nanoparticles in Different Liquids
(2024) Savinov,M.S.; Tikhonowski,G.V.; Pastukhov,A.I.; Fronya,A.A.; Klimentov,S.M.; Popov,A.A.; Савинов, Максим Сергеевич; Тихоновский, Глеб Валерьевич; Фроня, Анастасия Андреевна; Климентов, Сергей Михайлович; Попов, Антон Александрович
Только метаданные
Spectral Dependence of Bovine Coronavirus Photoinactivation under Irradiation by UV-A, UV-B, and UV-C Light-Emitting Diodes
(2024) Zavestovskaya,I.N.; Fronya,A.A.; Tupitsyn,I.M.; Cheshev,E.A.; Grigor’eva,M.S.; Mavreshko,E.I.; Завестовская, Ирина Николаевна; Фроня, Анастасия Андреевна; Чешев, Евгений Анатольевич; Григорьева, Мария Сергеевна; Маврешко, Егор Игоревич
Только метаданные
Inactivation of coronaviruses under irradiation by UVA-range light-emitting diodes
(2022) Gushchin, V. A.; Russu, L. I.; Cheshev, E. A.; Koromyslov, A. L.; Zavestovskaya, I. N.; Fronya, A. A.; Grigor'eva, M. S.; Завестовская, Ирина Николаевна; Фроня, Анастасия Андреевна; Григорьева, Мария Сергеевна
© 2022 Kvantovaya Elektronika and IOP Publishing Limited.We report the results of the development of an experimental stand based on UVA light-emitting diodes (UVA LEDs) with radiation wavelengths of 385 and 395 nm for studying experimentally the inactivation of viruses of the coronavirus family, including SARS-CoV-2. Methodological grounds are presented for determining the inactivation dose that provides a predetermined decrease in the virus titre under the impact of UVA radiation. The effect of the diode radiation divergence on the virus photoinactivation process is investigated. It is shown that UVA LEDs can be used to reduce the virus titre by 4 orders of magnitude.
Только метаданные
BEHAVIORAL FEATURES OF GALLIUM-68 RADIONUCLIDE INCORPORATED IN GLUCOSE DERIVATIVES IN LABORATORY ANIMALS
(2020) Petriev, V. M.; Tishchenko, V. K.; Stepchenkova, E. D.; Fedorov, O. V.; Fronya, A. A.; Фроня, Анастасия Андреевна
This work is devoted to a comparative study of pharmacokinetic properties of complex compounds labeled with gallium-68 aminoglucose (Ga-68-NODA-AG) or thioglucose (Ga-68-NODA-TG) in BALB/c mice after intravenous administration. Statistical significance of activity accumulation in most organs and tissues was observed only at 5 min post-injection. At the following terms, these values didn't have any statistical significance in most organs and tissues. Activity was eliminated from organs and tissues with high rate. The biological and effective half-lives of Ga-68-NODA-AG and Ga-68-NODA-TG from organs and tissues were less than 1 hour.
Только метаданные
Prospects for the Use of Bismuth Nanoparticles and Its Compounds in Biomedicine
(2023) Rudyy, A. V.; Fronya, A. A.; Zavestovskaya, I. N.; Фроня, Анастасия Андреевна; Завестовская, Ирина Николаевна