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Климентов, Сергей Михайлович

Научные группы

Научная группа

Организационные подразделения

Организационная единица

Инженерно-физический институт биомедицины

Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.

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Руководитель научной группы "Центр нанобиомедицины"

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Климентов

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Сергей Михайлович

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Теперь показываю 1 - 10 из 67

Только метаданные
Nanoparticles based on MIL-101 metal-organic frameworks as efficient carriers of therapeutic188Re radionuclide for nuclear medicine
(2024) Belyaev, I. B.; Zelepukin, I. V.; Petriev, V. M.; Klimentov, S. M.; Zavestovskaya, I. N.; Deyev, S. M.; Климентов, Сергей Михайлович; Завестовская, Ирина Николаевна; Деев, Сергей Михайлович
Только метаданные
Laser-ablative synthesis and photoheating characterization of TiN NPs for biomedical applications
(2022) Popov, A. A.; Tikhonowski, G. V.; Popova-Kuznetsova, E. A.; Klimentov, S. M.; Kabashin, A. V.; Попов, Антон Александрович; Тихоновский, Глеб Валерьевич; Попова-Кузнецова, Елена Алефтиновна; Климентов, Сергей Михайлович; Кабашин, Андрей Викторович
Titanium nitride (TiN) nanoparticles (NPs) prepared by methods of laser ablation in liquids present a novel object, which promises attractive biomedical applications. Here, we review our recent advances in the elaboration of femtosecond laser ablation technique from a TiN target in liquid medium (here, isopropanol) to maximize the efficiency of TiN NPs synthesis and optimize their characteristics. Our experiments showed that the synthesis productivity is dependent on lateral velocity of laser beam scanning during laser ablation with the achievement of productivity saturation at a certain relatively high velocity. The observed phenomenon was attributed to the interaction of laser pulses with cavitation bubbles generated during the ablation process. In addition, we assessed photo heating properties of the synthesized TiN NPs in the near-IR range. It was found that TiN NPs with sizes in 20-50 nm range have the highest heating rate and can be heated to maximal temperatures. As demonstrated by our recent tests in vitro and in vivo, this size range is optimal for biomedical applications, which promises successful applications of these nanoparticles in phototherapy and imaging modalities.
Открытый доступ
Boron Nanoparticle-Enhanced Proton Therapy for Cancer Treatment
(2023) Zavestovskaya, I. N.; Tikhonowski, G. V.; Savinov, M. S.; Shakhov, P. V.; Babkova, J. S.; Popov, A. A.; Klimentov, S. M.; Prasad, P. N.; Deyev, S. M.; Завестовская, Ирина Николаевна; Тихоновский, Глеб Валерьевич; Савинов, Максим Сергеевич; Шахов, Павел Владимирович; Бабкова, Юлия Сергеевна; Попов, Антон Александрович; Климентов, Сергей Михайлович; Деев, Сергей Михайлович
Proton therapy is one of the promising radiotherapy modalities for the treatment of deep-seated and unresectable tumors, and its efficiency can further be enhanced by using boron-containing substances. Here, we explore the use of elemental boron (B) nanoparticles (NPs) as sensitizers for proton therapy enhancement. Prepared by methods of pulsed laser ablation in water, the used B NPs had a mean size of 50 nm, while a subsequent functionalization of the NPs by polyethylene glycol improved their colloidal stability in buffers. Laser-synthesized B NPs were efficiently absorbed by MNNG/Hos human osteosarcoma cells and did not demonstrate any remarkable toxicity effects up to concentrations of 100 ppm, as followed from the results of the MTT and clonogenic assay tests. Then, we assessed the efficiency of B NPs as sensitizers of cancer cell death under irradiation by a 160.5 MeV proton beam. The irradiation of MNNG/Hos cells at a dose of 3 Gy in the presence of 80 and 100 ppm of B NPs led to a 2- and 2.7-fold decrease in the number of formed cell colonies compared to control samples irradiated in the absence of NPs. The obtained data unambiguously evidenced the effect of a strong proton therapy enhancement mediated by B NPs. We also found that the proton beam irradiation of B NPs leads to the generation of reactive oxygen species (ROS), which evidences a possible involvement of the non-nuclear mechanism of cancer cell death related to oxidative stress. Offering a series of advantages, including a passive targeting option and the possibility of additional theranostic functionalities based on the intrinsic properties of B NPs (e.g., photothermal therapy or neutron boron capture therapy), the proposed concept promises a major advancement in proton beam-based cancer treatment.
Только метаданные
Nonlinear photoacoustic response of suspensions of laser-synthesized plasmonic titanium nitride nanoparticles
(2020) Maldonado, M. E.; Das, A.; Gomes, A. S. L.; Popov, A. A.; Klimentov, S. M.; Kabashin, A. V.; Попов, Антон Александрович; Климентов, Сергей Михайлович; Кабашин, Андрей Викторович
© 2020 Optical Society of AmericaA nonlinear photoacoustic (PA) response from solutions of 40 nm plasmonic titanium nitride nanoparticles (NPs) synthesized by laser ablation in a liquid environment (acetone) is reported. Using a photoacoustic Z-scan with 5 ns pumping pulses, values of effective nonlinear absorption (NLA) coefficients βPA,eff were measured and found to be 3.27±0.17 × 10−8, 6.41±0.32 × 10−8, and 3.22±0.16 × 10−8 for 600, 700, and 800 nm pumping wavelengths, respectively. To take into account the influence of nonlinear scattering, absorption-dependent PA measurements were carried out together with the optical Z-scan, and the obtained data were compared. The origin of the effective absorptive nonlinearity is discussed based on combined NLA in NPs, nonlinear scattering, and bubble generation triggered by NP-mediated light absorption. Potential applications include biomedical diagnostics and therapy.
Только метаданные
Bismuth nanoparticles-enhanced proton therapy: Concept and biological assessment
(2024) Zavestovskaya, I. N.; Tikhonowski, G. V.; Savinov, M.; Shakhov, P. V.; Popov, A. A.; Klimentov, S. M.; Deyev, S. M.; Завестовская, Ирина Николаевна; Тихоновский, Глеб Валерьевич; Савинов, Максим Сергеевич; Шахов, Павел Владимирович; Попов, Антон Александрович; Климентов, Сергей Михайлович; Деев, Сергей Михайлович
Только метаданные
Cytotoxicity of Laser-Synthesized Nanoparticles of Elemental Bismuth
(2024) Shakhov, P. V.; Tikhonowski, G. V.; Popov, A. A.; Iliasov, A. R.; Lebedev, A. A.; Klimentov, S. M.; Шахов, Павел Владимирович; Тихоновский, Глеб Валерьевич; Попов, Антон Александрович; Илясов, Артём Романович; Лебедев, Анатолий Алексеевич; Климентов, Сергей Михайлович
Только метаданные
Germanium Nanoparticles Prepared by Laser Ablation in Low Pressure Helium and Nitrogen Atmosphere for Biophotonic Applications
(2022) Fronya, A. A.; Antonenko, S. V.; Karpov, N. V.; Pokryshkin, N. S.; Eremina, A. S.; Kharin, A. Y.; Dombrovska, Y. I.; Garmash, A. A.; Kargin, N. I.; Klimentov, S. M.; Timoshenko, V. Y.; Фроня, Анастасия Андреевна; Антоненко, Сергей Васильевич; Еремина, Анна Сергеевна; Гармаш, Александр Александрович; Каргин, Николай Иванович; Климентов, Сергей Михайлович; Тимошенко, Виктор Юрьевич
Due to particular physico-chemical characteristics and prominent optical properties, nanostructured germanium (Ge) appears as a promising material for biomedical applications, but its use in biological systems has been limited so far due to the difficulty of preparation of Ge nanostructures in a pure, uncontaminated state. Here, we explored the fabrication of Ge nanoparticles (NPs) using methods of pulsed laser ablation in ambient gas (He or He-N2 mixtures) maintained at low residual pressures (1-5 Torr). We show that the ablated material can be deposited on a substrate (silicon wafer in our case) to form a nanostructured thin film, which can then be ground in ethanol by ultrasound to form a stable suspension of Ge NPs. It was found that these formed NPs have a wide size dispersion, with sizes between a few nm and hundreds of nm, while a subsequent centrifugation step renders possible the selection of one or another NP size fraction. Structural characterization of NPs showed that they are composed of aggregations of Ge crystals, covered by an oxide shell. Solutions of the prepared NPs exhibited largely dominating photoluminescence (PL) around 450 nm, attributed to defects in the germanium oxide shell, while a separated fraction of relatively small (5-10 nm) NPs exhibited a red-shifted PL band around 725 nm under 633 nm excitation, which could be attributed to quantum confinement effects. It was also found that the formed NPs exhibit high absorption in the visible and near-IR spectral ranges and can be strongly heated under photoexcitation in the region of relative tissue transparency, which opens access to phototherapy functionality. Combining imaging and therapy functionalities in the biological transparency window, laser-synthesized Ge NPs present a novel promising object for cancer theranostics.
Только метаданные
Evolution of the properties of nanomaterials obtained by pulsed laser ablation
(2021) Faizullayeva, S.; Klimentov, S. M.; Popov, A. A.; Файзуллаева, Сабина Юсуповна; Климентов, Сергей Михайлович; Попов, Антон Александрович
The synthesis and application of metal and ceramic nanoparticle are significant subject in science and engineering. The metal nanoparticles such as gold, silver, and copper nanoparticles have more application in material science, nanomedicine, electronic, photonic, and art. One of the green methods for preparation of metal nanoparticles is laser ablation technique that offers a unique tool for nanofabrication of nanoparticles. In this work, gold colloids were prepared by pulsed laser ablation of high purity gold plate immersed in deionized water and 10µM NaCl solution. After ablation process, we study the change in the size distribution of nanoparticles after the ablation process for a month. © 2021 Institute of Physics Publishing. All rights reserved.
Только метаданные
Optimization of laser cleaning conditions using multimode short-pulse radiation
(2020) Kravchenko, Y. V.; Klimentov, S. M.; Derzhavin, S. I.; Mamonov, D. N.; Karpov, N. V.; Mayorov, A. N.; Климентов, Сергей Михайлович; Мамонов, Дмитрий Николаевич; Майоров, Алексей Николаевич
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.Aiming at significant enhancement of laser cleaning efficiency and productivity, we studied several typical experimental cases including removal of contaminated layers from absorbing surfaces, paying special attention to elimination of the thick rusty layers, and removal of absorbing coatings from transparent substrates. Nanosecond pulses of Nd:YAG laser were used in all the cases at variation of the mode content of the laser beam which was achieved by applying a multimode fiber delivery of radiation. Both, air and water ambient were used in the experiments. The results are discussed in terms of plasma microexplosions in the domain of the substrate–layer interface and the vapor bubbles formation inside the thick rusty layer impregnated with liquid.
Открытый доступ
High-order harmonic generation in au nanoparticle-contained plasmas
(2020) Venkatesh, M.; Ganeev, R. A.; Boltaev, G. S.; Kim, V. V.; Ivanov, D. S.; Kabashin, A. V.; Klimentov, S. M.; Иванов, Дмитрий Сергеевич; Кабашин, Андрей Викторович; Климентов, Сергей Михайлович
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.Gold nanoparticles (NPs) have a wide range of applications in various fields. Here, we present high-order nonlinear optical studies of the plasmas produced from ablation of Au bulk targets and Au NP films deposited on paper and glass substrates. Experimentally, we analyze high-order harmonic generation (HHG) from gold NPs-containing plasmas. The HHG is produced by 35-fs pulses at 800 and 400 nm, while the plasmas are produced by femtosecond (35 fs, 800 nm), picosecond (200 ps, 800 nm), and nanosecond (5 ns, 1064 nm) pulses, respectively. High-order harmonics produced from ablated Au NPs on paper were 40 times stronger than the HHG from that ablated from the Au bulk targets. Through molecular dynamic simulations, we investigate the formation of gold NPs during laser ablation of a metal surface under different conditions.