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Optical spectroanalyzer with extended dynamic range for pharmacokinetic investigations of photosensitizers in biotissue Оптическии спектроанализатор с расширенным динамическим диапазоном для фармакокинетических исследовании флуоресцирующих препаратов в биотканях

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dc.contributor.authorLinkov, K. G.
dc.contributor.authorMeerovich, G. A.
dc.contributor.authorAkhlyustina, E. V.
dc.contributor.authorSavelieva, T. A.
dc.contributor.authorLoschenov, V. B.
dc.contributor.authorМеерович, Геннадий Александрович
dc.contributor.authorАхлюстина, Екатерина Витальевна
dc.contributor.authorСавельева, Татьяна Александровна
dc.contributor.authorЛощенов, Виктор Борисович
dc.date.accessioned2024-11-20T10:56:04Z
dc.date.available2024-11-20T10:56:04Z
dc.date.issued2019
dc.description.abstract© 2019 Russian Photodynamic Association. All Rights Reserved. Currently, the most promising method for the study of pharmacokinetics of drugs with fluorescent properties is the spectral-fluorescent method. In this article, we propose an algorithm for expanding the dynamic range of the spectrum analyzer by automatically monitoring the maximum spectral density in the recorded fluorescence spectrum and automatically controlled changes in the accumulation time depending on this value, followed by compensation of the output signal with regard to this change, as well as hardware circuit solutions that allow this algorithm. Testing of LESA-01-"Biospeс" spectrum analyzer, upgraded using the proposed approach, was carried out on photosensitizer dispersions based on tetra-3-phenylthiophthalocyanine hydroxyaluminium of various concentrations (from 0.01 mg/l to 50 mg/l), approximately corresponding to the concentrations realized in the process of studying pharmacokinetics in calibration samples and tissues of experimental animals. The proposed solutions that implement the algorithm for recording fluorescence spectra with automatic change of accumulation time depending on the signal level, ensured a significant expansion of the dynamic range of the spectrum analyzer (up to 3.5 orders of magnitude) and improved accuracy in pharmacokinetic studies.
dc.format.extentС. 46-51
dc.identifier.citationOptical spectroanalyzer with extended dynamic range for pharmacokinetic investigations of photosensitizers in biotissue Оптическии спектроанализатор с расширенным динамическим диапазоном для фармакокинетических исследовании флуоресцирующих препаратов в биотканях / Linkov, K.G. [et al.] // Biomedical Photonics. - 2019. - 8. - № 1. - P. 46-51. - 10.24931/2413-9432-2019-8-1-46-51
dc.identifier.doi10.24931/2413-9432-2019-8-1-46-51
dc.identifier.urihttps://www.doi.org/10.24931/2413-9432-2019-8-1-46-51
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85063991808&origin=resultslist
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/16853
dc.relation.ispartofBiomedical Photonics
dc.titleOptical spectroanalyzer with extended dynamic range for pharmacokinetic investigations of photosensitizers in biotissue Оптическии спектроанализатор с расширенным динамическим диапазоном для фармакокинетических исследовании флуоресцирующих препаратов в биотканях
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume8
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