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The Combined Use of 5-ALA and Chlorin e6 Photosensitizers for Fluorescence-Guided Resection and Photodynamic Therapy under Neurophysiological Control for Recurrent Glioblastoma in the Functional Motor Area after Ineffective Use of 5-ALA: Preliminary Results

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dc.contributor.authorTrifonov, I. S.
dc.contributor.authorSinkin, M. V.
dc.contributor.authorKrylov, V. V.
dc.contributor.authorKozlikina, E. I.
dc.contributor.authorLoschenov, V. B.
dc.contributor.authorЛощенов, Виктор Борисович
dc.date.accessioned2024-12-26T09:12:36Z
dc.date.available2024-12-26T09:12:36Z
dc.date.issued2022
dc.description.abstract© 2022 by the authors. Licensee MDPI, Basel, Switzerland.The treatment of glial brain tumors is an unresolved problem in neurooncology, and all existing methods (tumor resection, chemotherapy, radiotherapy, radiosurgery, fluorescence diagnostics, photodynamic therapy, etc.) are directed toward increasing progression-free survival for patients. Fluorescence diagnostics and photodynamic therapy are promising methods for achieving gross total resection and additional treatment of residual parts of the tumor. However, sometimes the use of one photosensitizer for photodynamic therapy does not help, and the time until tumor relapse barely increases. This translational case report describes the preliminary results of the first combined use of 5-ALA and chlorin e6 photosensitizers for fluorescence-guided resection and photodynamic therapy of glioblastoma, which allowed us to perform total resection of tumor tissue according to magnetic resonance and computed tomography images, remove additional tissue with increased fluorescence intensity without neurophysiological consequences, and perform additional therapy. Two months after surgery, no recurrent tumor and no contrast uptake in the tumor bed were detected. Additionally, the patient had ischemic changes in the access zone and along the periphery and cystic-glial changes in the left parietal lobe.
dc.identifier.citationThe Combined Use of 5-ALA and Chlorin e6 Photosensitizers for Fluorescence-Guided Resection and Photodynamic Therapy under Neurophysiological Control for Recurrent Glioblastoma in the Functional Motor Area after Ineffective Use of 5-ALA: Preliminary Results / Trifonov, I.S. [et al.] // Bioengineering. - 2022. - 9. - № 3. - 10.3390/bioengineering9030104
dc.identifier.doi10.3390/bioengineering9030104
dc.identifier.urihttps://www.doi.org/10.3390/bioengineering9030104
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85125884818&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000776980600001
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/28810
dc.relation.ispartofBioengineering
dc.titleThe Combined Use of 5-ALA and Chlorin e6 Photosensitizers for Fluorescence-Guided Resection and Photodynamic Therapy under Neurophysiological Control for Recurrent Glioblastoma in the Functional Motor Area after Ineffective Use of 5-ALA: Preliminary Results
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue3
oaire.citation.volume9
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relation.isAuthorOfPublication.latestForDiscovery371640a5-5007-444c-a657-ccfac33ccebd
relation.isOrgUnitOfPublicationc8407a6f-7272-450d-8d99-032352c76b55
relation.isOrgUnitOfPublication.latestForDiscoveryc8407a6f-7272-450d-8d99-032352c76b55
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