Publication:
Mesoporous silicon nanoparticles loaded with salinomycin for cancer therapy applications

Простая страница элемента
dc.contributor.authorKonoplyannikov, M. A.
dc.contributor.authorLe-Deygen, I. M.
dc.contributor.authorYusubalieva, G. M.
dc.contributor.authorRevkova, V. A.
dc.contributor.authorEremina, A. S.
dc.contributor.authorKargina, Y. V.
dc.contributor.authorKharin, A.
dc.contributor.authorBazylenko, T. Y.
dc.contributor.authorTimoshenko, V. Y.
dc.contributor.authorЕремина, Анна Сергеевна
dc.contributor.authorБазыленко, Татьяна Юрьевна
dc.contributor.authorТимошенко, Виктор Юрьевич
dc.date.accessioned2024-11-29T21:14:15Z
dc.date.available2024-11-29T21:14:15Z
dc.date.issued2021
dc.description.abstract© 2021Mesoporous silicon nanoparticles loaded with salinomycin, a promising anticancer drug, were investigated as potential nanocontainers for cancer therapy. The drug loading and release were studied by means of the infrared spectroscopy, which revealed a gradual release of the drug with rate dependent on the mass ratio between the nanoparticles and salinomycin. In vitro studies revealed that the prepared nanoparticles loaded with salinomycin resulted in a notable cytotoxic effect on human glioblastoma cells, MCF-7 breast cancer cells and multidrug resistant MCF-7/MDR1 cells. In vivo experiments showed a strong suppression of the Lewis lung carcinoma tumor growth for 10–30 days after intraperitoneal administration of the nanocontainers. The obtained results indicate that salinomycin-loaded mesoporous silicon nanoparticles are prospective for mild chemotherapy of both primary cancer tumors and metastasis. The revealed efficiency against chemotherapy-resistant cancer stem cells and possibility of the intraperitoneal administration are very promising for further clinical applications of the prepared nanocontainers.
dc.identifier.citationMesoporous silicon nanoparticles loaded with salinomycin for cancer therapy applications / Konoplyannikov, M.A. [et al.] // Microporous and Mesoporous Materials. - 2021. - 328. - 10.1016/j.micromeso.2021.111473
dc.identifier.doi10.1016/j.micromeso.2021.111473
dc.identifier.urihttps://www.doi.org/10.1016/j.micromeso.2021.111473
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85116876797&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000709958600006
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/24783
dc.relation.ispartofMicroporous and Mesoporous Materials
dc.titleMesoporous silicon nanoparticles loaded with salinomycin for cancer therapy applications
dc.typeArticle
dspace.entity.typePublication
oaire.citation.volume328
relation.isAuthorOfPublication2f277143-d497-43d0-94a0-01d14a4be67c
relation.isAuthorOfPublication57ce8f8d-6cb5-453f-bcf3-eeb897754b5c
relation.isAuthorOfPublication4cf6bcf1-0992-45ed-af93-68678d96a4da
relation.isAuthorOfPublication.latestForDiscovery2f277143-d497-43d0-94a0-01d14a4be67c
relation.isOrgUnitOfPublicationc8407a6f-7272-450d-8d99-032352c76b55
relation.isOrgUnitOfPublication.latestForDiscoveryc8407a6f-7272-450d-8d99-032352c76b55
Файлы
Коллекции
Публикации