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Studying the genotoxic effects of high intensity terahertz radiation on fibroblasts and CNS tumor cells

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dc.contributor.authorSitnikov, D. S.
dc.contributor.authorRevkova, V. A.
dc.contributor.authorIlina, I. V.
dc.contributor.authorGurova, S. A.
dc.contributor.authorKomarov, P. S.
dc.contributor.authorStruleva, E. V.
dc.contributor.authorKonoplyannikov, M. A.
dc.contributor.authorKalsin, V. A.
dc.contributor.authorBaklaushev, V. P.
dc.date.accessioned2024-12-28T08:06:53Z
dc.date.available2024-12-28T08:06:53Z
dc.date.issued2023
dc.description.abstractThe data is obtained on the effect of high-intensity pulses of terahertz (THz) radiation with a broad spectrum (0.2–3 THz) on cell cultures. We have evaluated the threshold exposure parameters of THz radiation causing genotoxic effects in fibroblasts. Phosphorylation of histone H2AX at Ser 139 (γH2AX) was chosen as a marker for genotoxicity and a quantitative estimation of γH2AX foci number in fibroblasts was performed after cell irradiation with THz pulses for 30 min. No genotoxic effects of THz radiation were observed in fibroblasts unless peak intensity and electric field strength exceeded 21 GW cm−2 and 2.8 MV cm−1, respectively. In tumor cell lines (neuroblastoma (SK-N-BE (2)) and glioblastoma (U87)), exposure to THz pulses with peak intensity of 21 GW cm−2 for 30 min caused no morphological changes as well as no statistically significant increase in histone phosphorylation foci number. © 2022 Wiley-VCH GmbH.
dc.identifier.citationStudying the genotoxic effects of high intensity terahertz radiation on fibroblasts and CNS tumor cells / Sitnikov, D.S. [et al.] // Journal of Biophotonics. - 2023. - 10.1002/jbio.202200212
dc.identifier.doi10.1002/jbio.202200212
dc.identifier.urihttps://www.doi.org/10.1002/jbio.202200212
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85141392666&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000873899600001
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/29875
dc.relation.ispartofJournal of Biophotonics
dc.subjectfibroblasts
dc.subjectgenotoxic effects
dc.subjectglioblastoma
dc.subjectneuroblastoma
dc.subjectterahertz radiation
dc.subjectγH2AX
dc.titleStudying the genotoxic effects of high intensity terahertz radiation on fibroblasts and CNS tumor cells
dc.typeLetter
dspace.entity.typePublication
relation.isOrgUnitOfPublication4b108cd7-08a1-4350-ab3f-20450dec091d
relation.isOrgUnitOfPublication.latestForDiscovery4b108cd7-08a1-4350-ab3f-20450dec091d
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