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Stem cell therapy for vocal fold regeneration after scarring: a review of experimental approaches

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dc.contributor.authorSvistushkin, M. V.
dc.contributor.authorKotova, S.
dc.contributor.authorShpichka, A.
dc.contributor.authorStarostina, S.
dc.contributor.authorTimashev, S.
dc.contributor.authorТимашев, Сергей Федорович
dc.date.accessioned2024-12-26T11:41:12Z
dc.date.available2024-12-26T11:41:12Z
dc.date.issued2022
dc.description.abstract© 2022, The Author(s).This review aims at becoming a guide which will help to plan the experimental design and to choose adequate methods to assess the outcomes when testing cell-based products in the treatment of the damaged vocal folds. The requirements to preclinical trials of cell-based products remain rather hazy and dictated by the country regulations. Most parameters like the way the cells are administered, selection of the cell source, selection of a carrier, and design of in vivo studies are decided upon by each research team and may differ essentially between studies. The review covers the methodological aspects of preclinical studies such as experimental models, characterization of cell products, assessment of the study outcome using molecular, morphological and immunohistochemical analyses, as well as measuring the tissue physical properties. The unified recommendations to perform preclinical trials could significantly facilitate the translation of cell-based products into the clinical practice. Graphical abstract: [Figure not available: see fulltext.]
dc.identifier.citationStem cell therapy for vocal fold regeneration after scarring: a review of experimental approaches / Svistushkin, M.V. [et al.] // Stem Cell Research and Therapy. - 2022. - 13. - № 1. - 10.1186/s13287-022-02853-9
dc.identifier.doi10.1186/s13287-022-02853-9
dc.identifier.urihttps://www.doi.org/10.1186/s13287-022-02853-9
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85129292325&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000790188500002
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/29041
dc.relation.ispartofStem Cell Research and Therapy
dc.titleStem cell therapy for vocal fold regeneration after scarring: a review of experimental approaches
dc.typeReview
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume13
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relation.isAuthorOfPublication.latestForDiscovery335de349-29a3-4bc6-8b5d-f553a65beaf6
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