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The Spectroscopic Study of Indocyanine Green J-Aggregate Stability in Human Blood and Plasma

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dc.contributor.authorFarrakhova, D. S.
dc.contributor.authorRomanishkin, I. D.
dc.contributor.authorYakovlev, D. V.
dc.contributor.authorMaklygina, Y. S.
dc.contributor.authorSavelieva, T. A.
dc.contributor.authorLoschenov, V. B.
dc.contributor.authorСавельева, Татьяна Александровна
dc.contributor.authorЛощенов, Виктор Борисович
dc.date.accessioned2024-12-26T11:35:34Z
dc.date.available2024-12-26T11:35:34Z
dc.date.issued2022
dc.description.abstract© 2022, Allerton Press, Inc.Abstract: Spectroscopic approaches are very good to noninvasively determine the most significant indicators of the tissue state. Indocyanine green (ICG) is a well-known fluorescent dye approved for clinical applications, which has a short circulation time in the vascular system and low photostability. At high temperatures the molecular solution of the photosensitizer self-assembles into a stable J-aggregate form of ICG nanoparticles (ICG NPs) with the absorption peak in the near-infrared range. Investigation of ICG NP stability in human blood and plasma using a fiber-spectroscopic system demonstrates no difference in absorption properties and different dependence of the integrated fluorescence ratio between ICG monomers and J-aggregates in blood and plasma. Transition of ICG NP aggregates to the monomeric form in human blood plasma results in a higher circulation time of the fluorescent dye in the vascular system. High stability of aggregates and a low elimination rate may increase efficiency of fluorescent diagnostics of near-tumor tissues.
dc.format.extentС. 86-90
dc.identifier.citationThe Spectroscopic Study of Indocyanine Green J-Aggregate Stability in Human Blood and Plasma / Farrakhova, D.S. [et al.] // Physics of Wave Phenomena. - 2022. - 30. - № 2. - P. 86-90. - 10.3103/S1541308X22020029
dc.identifier.doi10.3103/S1541308X22020029
dc.identifier.urihttps://www.doi.org/10.3103/S1541308X22020029
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85128832397&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000786438100002
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/29033
dc.relation.ispartofPhysics of Wave Phenomena
dc.titleThe Spectroscopic Study of Indocyanine Green J-Aggregate Stability in Human Blood and Plasma
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue2
oaire.citation.volume30
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relation.isAuthorOfPublication.latestForDiscovery828b252d-b959-4fea-851c-89776ac96b94
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