Publication:
Influence of Pulsed He-Ne Laser Irradiation on the Red Blood Cell Interaction Studied by Optical Tweezers

Файлы
W2994473843.pdf(2.1 MB)
Дата
2019
Авторы
Zhu, R.
Avsievich, T.
Bykov, A.
Popov, A.
Meglinski, I.
Journal Title
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Volume Title
Издатель
Научные группы
Организационные подразделения
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Организационная единица
Инженерно-физический институт биомедицины
Цель ИФИБ и стратегия развития – это подготовка высококвалифицированных кадров на базе передовых исследований и разработок новых перспективных методов и материалов в области инженерно-физической биомедицины. Занятие лидерских позиций в биомедицинских технологиях XXI века и внедрение их в образовательный процесс, что отвечает решению практикоориентированной задачи мирового уровня – диагностике и терапии на клеточном уровне социально-значимых заболеваний человека.
Выпуск журнала
Аннотация
Optical Tweezers (OT), as a revolutionary innovation in laser physics, has been extremely useful in studying cell interaction dynamics at a single-cell level. The reversible aggregation process of red blood cells (RBCs) has an important influence on blood rheological properties, but the underlying mechanism has not been fully understood. The regulating effects of low-level laser irradiation on blood rheological properties have been reported. However, the influence of pulsed laser irradiation, and the origin of laser irradiation effects on the interaction between RBCs remain unclear. In this study, RBC interaction was assessed in detail with OT. The effects of both continuous and pulsed low-level He-Ne laser irradiation on RBC aggregation was investigated within a short irradiation period (up to 300 s). The results indicate stronger intercellular interaction between RBCs in the enforced disaggregation process, and both the cell contact time and the initial contact area between two RBCs showed an impact on the measured disaggregation force. Meanwhile, the RBC aggregation force that was independent to measurement conditions decreased after a short time of pulsed He-Ne laser irradiation. These results provide new insights into the understanding of the RBC interaction mechanism and laser irradiation effects on blood properties.
Описание
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Цитирование
Influence of Pulsed He-Ne Laser Irradiation on the Red Blood Cell Interaction Studied by Optical Tweezers / Zhu, R [et al.] // Micromachines. - 2019. - 10. - № 12. - 10.3390/mi10120853
URI
https://www.doi.org/10.3390/mi10120853
 https://www.scopus.com/record/display.uri?eid=2-s2.0-85079123198&origin=resultslist
 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000507337900041
 https://openrepository.mephi.ru/handle/123456789/19374
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