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Pharmaceutical Approach to Develop Novel Photosensitizer Nanoformulation: An Example of Design and Characterization Rationale of Chlorophyll α Derivative

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dc.contributor.authorSokol, M. B.
dc.contributor.authorBeganovskaya, V. A.
dc.contributor.authorMollaeva, M. R.
dc.contributor.authorYabbarov, N. G.
dc.contributor.authorKuzmin, V. A.
dc.contributor.authorКузьмин, Владимир Александрович
dc.date.accessioned2024-12-04T08:36:21Z
dc.date.available2024-12-04T08:36:21Z
dc.date.issued2024
dc.description.abstractIn this study, we described physico-chemical properties of novel nanoformulation of photosensitizer-pyropheophorbide Ћ? 17-diethylene glycol ester (XL) (chlorophyll Ћ? derivative), revealing insights into antitumor activity and maintaining quality, meeting the pharmaceutical approach of new nanoformulation design. Our formulation, based on poly(lactic-co-glycolic acid) (PLGA) nanoparticles, increased XL solubility and selective tumor-targeted accumulation. In our research, we revealed, for the first time, that XL binding to polyvinyl alcohol (PVA) enhances XL photophysical activity, providing the rationale for PVA application as a stabilizer for nanoformulations. Results of FTIR, DSC, and XRD revealed the physical interactions between XL and excipients, including PVA, indicating that the encapsulation maintained XL binding to PVA. The encapsulated XL exhibited higher photophysical activity compared to non-encapsulated substance, which can be attributed to the influence of residual PVA. Gamma-irradiation led to degradation of XL; however, successful sterilization of the samples was achieved through the filtration. Importantly, the encapsulated and sterilized XL retained cytotoxicity against both 2D and 3D tumor cell models, demonstrating the potential of the formulated NPў??XL for photodynamic therapy applications, but lacked the ability to reactivate epigenetically silenced genes. These findings provide valuable insights into the design and characterization of PLGA-based nanoparticles for the encapsulation of photosensitizers.
dc.identifier.citationPharmaceutical Approach to Develop Novel Photosensitizer Nanoformulation: An Example of Design and Characterization Rationale of Chlorophyll α Derivative / Sokol, M. B. [et al.] // Pharmaceutics. - 2024. - 16. - № 1. - 10.3390/pharmaceutics16010126
dc.identifier.doi10.3390/pharmaceutics16010126
dc.identifier.urihttps://www.doi.org/10.3390/pharmaceutics16010126
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85183126249&origin=resultslist
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/25781
dc.relation.ispartofPharmaceutics
dc.subjectPolyvinyl alcohol
dc.subjectPhotosensitizers
dc.titlePharmaceutical Approach to Develop Novel Photosensitizer Nanoformulation: An Example of Design and Characterization Rationale of Chlorophyll α Derivative
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume16
relation.isAuthorOfPublication866e495e-aa4d-4e41-b465-9b042d3163c0
relation.isAuthorOfPublication.latestForDiscovery866e495e-aa4d-4e41-b465-9b042d3163c0
relation.isOrgUnitOfPublicationc8407a6f-7272-450d-8d99-032352c76b55
relation.isOrgUnitOfPublication.latestForDiscoveryc8407a6f-7272-450d-8d99-032352c76b55
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