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Influence of multiplexing conditions on artefact signal and the signal-to-noise ratio in the decoded data in Hadamard transform ion mobility spectrometry

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dc.contributor.authorSarycheva, A.
dc.contributor.authorAdamov, A.
dc.contributor.authorPoteshin, S. S.
dc.contributor.authorLagunov, S. S.
dc.contributor.authorSysoev, A. A.
dc.contributor.authorАдамов, Алексей Юрьевич
dc.contributor.authorПотешин, Сергей Станиславович
dc.contributor.authorЛагунов, Сергей Сергеевич
dc.contributor.authorСысоев, Алексей Александрович
dc.date.accessioned2024-11-25T15:51:23Z
dc.date.available2024-11-25T15:51:23Z
dc.date.issued2020
dc.description.abstractIn Hadamard transform ion mobility spectrometry (HT IMS), the signal-to-noise ratio is always lower for non-modified pseudorandom sequences than for modified sequences. Since the use of non-modified modulating pseudorandom sequences is strategically preferable from a duty cycle standpoint, we investigated the change in the interference signal when transitioning from non-modified modulating sequences to sequences modified by the addition of 1,3,5 and 7 zeros. The interfering signal in HT IMS with modified pseudorandom sequences was shown to be mainly random noise for all the cases except for modifying by incorporation of 1 zero. For standard samples of tetraalkylammonium halides, modulation by non-modified pseudorandom sequences is beneficial in the case of small numbers of averaged spectra (below similar to 40 averaged spectra compared to any modified pseudorandom sequences except for 1 zero modified and below similar to 200 averaged spectra compared to signal averaging ion mobility spectrometry) and worsens the signal-to-noise ratio in the case of large numbers of averaged spectra. Contrarily, modulation by modified pseudorandom sequences is beneficial for any number of averaged spectra, except for very small ones (below 15 averaged spectra compared to modulation by non-modified sequences). Pseudorandom sequence modified with 1 zero incorporation is beneficial in the case of below similar to 400 averaged spectra compared to any modified and non-modified pseudorandom sequences. The signal-to-noise ratio in conventional signal averaging mode ion mobility spectrometry is affected by random noise, whereas the HT IMS with non-modified pseudorandom sequences was demonstrated to be primarily affected by a systematic noise-like artefact signal. Because noise-like artefact signals were found to be reproducible, predicting models for interference signals could be generated to improve signal-to-noise ratio. This is significant because non-modified modulating sequences are limited by their poor signal-to-noise ratio. This improvement would increase the viability of non-modified modulating sequences which are preferred because of their higher sample utilization efficiency.
dc.identifier.citationInfluence of multiplexing conditions on artefact signal and the signal-to-noise ratio in the decoded data in Hadamard transform ion mobility spectrometry / Sarycheva, A [et al.] // European Journal of Mass Spectrometry. - 2020. - 10.1177/1469066719900763
dc.identifier.doi10.1177/1469066719900763
dc.identifier.urihttps://www.doi.org/10.1177/1469066719900763
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85078485563&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000509321800001
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/20200
dc.relation.ispartofEuropean Journal of Mass Spectrometry
dc.titleInfluence of multiplexing conditions on artefact signal and the signal-to-noise ratio in the decoded data in Hadamard transform ion mobility spectrometry
dc.typeArticle
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