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Stimulus-Sensitive Theranostic Delivery Systems Based on Microcapsules Encoded with Quantum Dots and Magnetic Nanoparticles

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dc.contributor.authorRamos-Gomes, F.
dc.contributor.authorAlves, F.
dc.contributor.authorSukhanova, A.
dc.contributor.authorNifontova, G.
dc.contributor.authorNabiev, I.
dc.contributor.authorНифонтова, Галина Олеговна
dc.contributor.authorНабиев, Игорь Руфаилович
dc.date.accessioned2024-11-25T18:13:27Z
dc.date.available2024-11-25T18:13:27Z
dc.date.issued2020
dc.description.abstractFluorescent semiconductor nanocrystals, known as quantum dots (QDs), and magnetic nanoparticles (MNPs) are extensively studied perspective tools for optical (fluorescence) and magnetic resonance imaging techniques. The unique optical properties, high photostability, and bright luminescence of QDs make them more promising fluorophores than the classical organic dyes. Encoding polyelectrolyte microcapsules with QDs and MNPs ensures their sensitivity to both photoexcitation and magnetic field. This chapter presents the protocol for obtaining a stimulus-sensitive delivery system based on QD- and MNP-encoded polyelectrolyte microcapsules by means of layer-by-layer self-assembly. The resultant fluorescent magnetic polyelectrolyte microcapsules are 3.4-5.5 μm in size, have a hollow structure, and are brightly fluorescent to be detected with the standard imaging equipment. Polyelectrolyte microcapsule surface bears functional groups for subsequent functionalization with vector capture molecules. The polyelectrolyte microcapsules containing combination of QDs and MNPs are advanced visualization tools, since they can be sorted in a magnetic field and at the same time are suitable for fluorescent imaging what can be applied within a wide range of diagnostic and therapeutic protocols.
dc.format.extentС. 199-212
dc.identifier.citationStimulus-Sensitive Theranostic Delivery Systems Based on Microcapsules Encoded with Quantum Dots and Magnetic Nanoparticles / Ramos-Gomes, F. [et al.] // Methods in Molecular Biology. - 2020. - 2135. - P. 199-212. - 10.1007/978-1-0716-0463-2_11
dc.identifier.doi10.1007/978-1-0716-0463-2_11
dc.identifier.urihttps://www.doi.org/10.1007/978-1-0716-0463-2_11
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85083042163&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000680965100012
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/20605
dc.relation.ispartofMethods in Molecular Biology
dc.titleStimulus-Sensitive Theranostic Delivery Systems Based on Microcapsules Encoded with Quantum Dots and Magnetic Nanoparticles
dc.typeBook Chapter
dspace.entity.typePublication
oaire.citation.volume2135
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