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Laser-Synthesized Germanium Nanoparticles as Biodegradable Material for Near-Infrared Photoacoustic Imaging and Cancer Phototherapy

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dc.contributor.authorBelyaev, I. B.
dc.contributor.authorZelepukin, I. V.
dc.contributor.authorKotelnikova, P. A.
dc.contributor.authorTikhonowski, G. V.
dc.contributor.authorPopov, A. A.
dc.contributor.authorKopylov, A. N.
dc.contributor.authorDeyev, S. M.
dc.contributor.authorТихоновский, Глеб Валерьевич
dc.contributor.authorПопов, Антон Александрович
dc.contributor.authorКопылов, Алексей Николаевич
dc.contributor.authorДеев, Сергей Михайлович
dc.date.accessioned2024-12-04T10:17:50Z
dc.date.available2024-12-04T10:17:50Z
dc.date.issued2024
dc.description.abstractAbstract Biodegradable nanomaterials can significantly improve the safety profile of nanomedicine. Germanium nanoparticles (Ge NPs) with a safe biodegradation pathway are developed as efficient photothermal converters for biomedical applications. Ge NPs synthesized by femtosecondў??laser ablation in liquids rapidly dissolve in physiologicalў??like environment through the oxidation mechanism. The biodegradation of Ge nanoparticles is preserved in tumor cells in vitro and in normal tissues in mice with a halfў??life as short as 3.5 days. Biocompatibility of Ge NPs is confirmed in vivo by hematological, biochemical, and histological analyses. Strong optical absorption of Ge in the nearў??infrared spectral range enables photothermal treatment of engrafted tumors in vivo, following intravenous injection of Ge NPs. The photothermal therapy results in a 3.9ў??fold reduction of the EMT6/P adenocarcinoma tumor growth with significant prolongation of the mice survival. Excellent massў??extinction of Ge NPs (7.9 L g ў??1 cm ў??1 at 808 nm) enables photoacoustic imaging of bones and tumors, following intravenous and intratumoral administrations of the nanomaterial. As such, strongly absorbing nearў??infraredў??light biodegradable Ge nanomaterial holds promise for advanced theranostics.
dc.identifier.citationLaser-Synthesized Germanium Nanoparticles as Biodegradable Material for Near-Infrared Photoacoustic Imaging and Cancer Phototherapy / Belyaev, I. B. [et al.] // Advanced Science. - 2024. - 10.1002/advs.202307060
dc.identifier.doi10.1002/advs.202307060
dc.identifier.urihttps://www.doi.org/10.1002/advs.202307060
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85188244327&origin=resultslist
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/25894
dc.relation.ispartofAdvanced Science
dc.subjectBiocompatibility
dc.subjectNanomaterials
dc.subjectBiomimetic Nanoparticles
dc.subjectMetal Nanoparticles
dc.subjectNanoparticle Synthesis
dc.subjectBioimaging
dc.subjectPhotothermal Therapy
dc.titleLaser-Synthesized Germanium Nanoparticles as Biodegradable Material for Near-Infrared Photoacoustic Imaging and Cancer Phototherapy
dc.typeArticle
dspace.entity.typePublication
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