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DARPin_9-29-targeted gold nanorods selectively suppress her2-positive tumor growth in mice

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dc.contributor.authorProshkina, G. M.
dc.contributor.authorShramova, E. I.
dc.contributor.authorShilova, M. V.
dc.contributor.authorRyabova, A. V.
dc.contributor.authorZelepukin, I. V.
dc.contributor.authorShipunova, V. O.
dc.contributor.authorDeyev, S. M.
dc.contributor.authorДеев, Сергей Михайлович
dc.date.accessioned2024-11-29T21:33:47Z
dc.date.available2024-11-29T21:33:47Z
dc.date.issued2021
dc.description.abstract© 2021 by the authors. Licensee MDPI, Basel, Switzerland.Near-infrared phototherapy has great therapeutic potential for cancer treatment. How-ever, for efficient application, in vivo photothermal agents should demonstrate excellent stability in blood and targeted delivery to pathological tissue. Here, we demonstrated that stable bovine serum albumin-coated gold mini nanorods conjugated to a HER2-specific designed ankyrin repeat protein, DARPin_9-29, selectively accumulate in HER2-positive xenograft tumors in mice and lead to a strong reduction in the tumor size when being illuminated with near-infrared light. The results pave the way for the development of novel DARPin-based targeted photothermal therapy of cancer.
dc.identifier.citationDARPin_9-29-targeted gold nanorods selectively suppress her2-positive tumor growth in mice / Proshkina, G.M. [et al.] // Cancers. - 2021. - 13. - № 20. - 10.3390/cancers13205235
dc.identifier.doi10.3390/cancers13205235
dc.identifier.urihttps://www.doi.org/10.3390/cancers13205235
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85117177418&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000715463700001
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/24816
dc.relation.ispartofCancers
dc.titleDARPin_9-29-targeted gold nanorods selectively suppress her2-positive tumor growth in mice
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue20
oaire.citation.volume13
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relation.isAuthorOfPublication.latestForDiscovery66f50b35-0e92-49e0-ad1a-0ac386d858b7
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