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An approach to computer analysis of the ligand binding assay data on example of radioligand assay data

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dc.contributor.authorFedotov, S. N.
dc.contributor.authorФедотов, Сергей Николаевич
dc.date.accessioned2024-11-26T12:50:54Z
dc.date.available2024-11-26T12:50:54Z
dc.date.issued2020
dc.description.abstract© 2020 World Scientific Publishing Europe Ltd.As a rule, receptor-ligand assay data are fitted by logistic functions (4PL model, 5PL model, Feldman's model). The preparation of the initial estimates for parameters of these functions is an important problem for processing receptor-ligand interaction data. This study represents a new mathematical approach to calculate the initial estimates more closely to the true values of parameters. The main idea of this approach is in using the modified linear least squares method for calculations of the parameters for the 4PL model and the Feldman's model. In this study, the convergence of model parameters to true values is verified for the simulated data with different statistical scatter. Also, the results of processing real data for the 4PL model and the Feldman's model are presented. A comparison is made of the parameter values calculated by the presented and a nonlinear method. The developed approach has demonstrated its efficiency in calculating the parameters of the complex Feldman"s models up to 4 ligands and 4 sites.
dc.identifier.citationFedotov, S. N. An approach to computer analysis of the ligand binding assay data on example of radioligand assay data / Fedotov, S.N. // Journal of Bioinformatics and Computational Biology. - 2020. - 10.1142/S0219720020500146
dc.identifier.doi10.1142/S0219720020500146
dc.identifier.urihttps://www.doi.org/10.1142/S0219720020500146
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85084324719&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000533639000009
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/21656
dc.relation.ispartofJournal of Bioinformatics and Computational Biology
dc.titleAn approach to computer analysis of the ligand binding assay data on example of radioligand assay data
dc.typeArticle
dspace.entity.typePublication
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