Publication:
Perfluorocarbon Nanoemulsions with Fluorous Chlorin-Type Photosensitizers for Antitumor Photodynamic Therapy in Hypoxia

Простая страница элемента
dc.contributor.authorNguyen, M. T.
dc.contributor.authorGuseva, E. V.
dc.contributor.authorAtaeva, A. N.
dc.contributor.authorSigan, A. L.
dc.contributor.authorShtil, A. A.
dc.contributor.authorШтиль, Александр Альбертович
dc.date.accessioned2024-12-28T10:44:45Z
dc.date.available2024-12-28T10:44:45Z
dc.date.issued2023
dc.description.abstractThe efficacy of photodynamic therapy (PDT) strictly depends on the availability of molecular oxygen to trigger the light-induced generation of reactive species. Fluorocarbons have an increased ability to dissolve oxygen and are attractive tools for gas delivery. We synthesized three fluorous derivatives of chlorin with peripheral polyfluoroalkyl substituents. These compounds were used as precursors for preparing nanoemulsions with perfluorodecalin as an oxygen depot. Therefore, our formulations contained hydrophobic photosensitizers capable of absorbing monochromatic light in the long wavelength region and the oxygen carrier. These modifications did not alter the photosensitizing characteristics of chlorin such as the generation of singlet oxygen, the major cytocidal species in PDT. Emulsions readily entered HCT116 colon carcinoma cells and accumulated largely in mitochondria. Illumination of cells loaded with emulsions rapidly caused peroxidation of lipids and the loss of the plasma membrane integrity (photonecrosis). Most importantly, in PDT settings, emulsions potently sensitized cells cultured under prolonged (8 weeks) hypoxia as well as cells after oxygen depletion with sodium sulfite (acute hypoxia). The photodamaging potency of emulsions in hypoxia was significantly more pronounced compared to emulsion-free counterparts. Considering a negligible dark cytotoxicity, our materials emerge as efficient and biocompatible instruments for PDT-assisted eradication of hypoxic cells.
dc.identifier.citationPerfluorocarbon Nanoemulsions with Fluorous Chlorin-Type Photosensitizers for Antitumor Photodynamic Therapy in Hypoxia / Nguyen, M. T. [et al.] // International Journal of Molecular Sciences. - 2023. - 24. - № 9. - 10.3390/ijms24097995
dc.identifier.doi10.3390/ijms24097995
dc.identifier.urihttps://www.doi.org/10.3390/ijms24097995
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85159328007&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000987543300001
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/30157
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.subjectChlorin
dc.subjectPhotosensitizers
dc.subjectPhotodynamic Therapy
dc.subjectPhotothermal Therapy
dc.titlePerfluorocarbon Nanoemulsions with Fluorous Chlorin-Type Photosensitizers for Antitumor Photodynamic Therapy in Hypoxia
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue9
oaire.citation.volume24
relation.isAuthorOfPublicationd2e4a764-d93d-47f5-a8bc-09f718b121f7
relation.isAuthorOfPublication.latestForDiscoveryd2e4a764-d93d-47f5-a8bc-09f718b121f7
relation.isOrgUnitOfPublication010157d0-1f75-46b2-ab5b-712e3424b4f5
relation.isOrgUnitOfPublication.latestForDiscovery010157d0-1f75-46b2-ab5b-712e3424b4f5
Файлы
Original bundle
Теперь показываю 1 - 1 из 1
Уменьшенное изображение
Name:
W4367319957.pdf
Size:
3.66 MB
Format:
Adobe Portable Document Format
Description:
Download
Коллекции
Публикации