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STUdy OF ENERGy TRANSFER pROCESSES BETWEEN RARE EARTh IONS ANd phOTOSENSITIZER mOLECULES FOR phOTOdyNAmIC ThERApy WITh IR-EXCITATION ИССЛЕдОвАНИЕ пРОЦЕССОв пЕРЕдАчИ ЭНЕРГИИ мЕЖдУ РЕдКОЗЕмЕЛЬНЫмИ ИОНАмИ И мОЛЕКУЛАмИ фОТОСЕНСИБИЛИЗАТОРОв дЛя ЗАдАч фОТОдИНАмИчЕСКОи ТЕРАпИИ С вОЗБУЖдЕНИЕм в ИК-дИАпАЗОНЕ

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dc.contributor.authorProydakova, V. Y.
dc.contributor.authorRomanishkin, I. D.
dc.contributor.authorKuznetsov, S. V.
dc.contributor.authorLukyanets, E. A.
dc.contributor.authorPominova, D. V.
dc.contributor.authorBogatova, A. S.
dc.contributor.authorAkhlyustina, E. V.
dc.contributor.authorSaveleva, T. A.
dc.contributor.authorLoschenov, V. B.
dc.contributor.authorПоминова, Дарья Вячеславовна
dc.contributor.authorАхлюстина, Екатерина Витальевна
dc.contributor.authorСавельева, Татьяна Александровна
dc.contributor.authorЛощенов, Виктор Борисович
dc.date.accessioned2024-11-30T02:24:24Z
dc.date.available2024-11-30T02:24:24Z
dc.date.issued2021
dc.description.abstract© 2021 Russian Photodynamic Association. All rights reserved.Today, photodynamic therapy is one of the most promising minimally invasive methods of treatment of various diseases, including cancer. The main limitation of this method is the insufficient penetration into the tissue of laser radiation used to activate photosensitizer molecules,which makes it difficult to carry out therapy in the treatment of large or deep-seated tumors. In this regard, there is a great interest in thedevelopment of new strategies for photodynamic therapy using infrared radiation for excitation, the wavelengths of which fall into the “transparencywindow” of biological tissues. In this work, it was proposed to use upconversion NaGdF4:Yb:Er nanoparticles (UCNP), which absorbinfrared excitation and serve as a donor that transfers energy to the photosensitizer. Photosens and phthalosens were chosen as the mostpromising photosensitizers for the study. The aim of this work was to study the energy transfer processes between upconversion nanoparticlesdoped with rare-earth ions and photosensitizer molecules. in order to excite photosensitizers with IR radiation and carry out photodynamictherapy of deep-seated neoplasms. Using spectroscopic and time-resolved methods, it has been demonstrated that there is an efficientenergy transfer between upconversion particles and photosensitizers phthalosens and photosens. The calculated efficiency of energy transferby the Foerster mechanism was 41% for the UCNP + photosens system and 69% for the UCNP + phthalosens system. It has been experimentallyand theoretically proved that there is a binding of photosensitizer molecules with UCNP by means of surfactants, leading to a reductionin the distance between them, due to which effective nonradiative energy transfer is realized. The generation of singlet oxygen by the phthalosensphotosensitizer upon excitation by means of energy transfer from UCNP, excited at 980 nm wavelength of, has been demonstrated.
dc.format.extentС. 23-34
dc.identifier.citationSTUdy OF ENERGy TRANSFER pROCESSES BETWEEN RARE EARTh IONS ANd phOTOSENSITIZER mOLECULES FOR phOTOdyNAmIC ThERApy WITh IR-EXCITATION ИССЛЕдОвАНИЕ пРОЦЕССОв пЕРЕдАчИ ЭНЕРГИИ мЕЖдУ РЕдКОЗЕмЕЛЬНЫмИ ИОНАмИ И мОЛЕКУЛАмИ фОТОСЕНСИБИЛИЗАТОРОв дЛя ЗАдАч фОТОдИНАмИчЕСКОи ТЕРАпИИ С вОЗБУЖдЕНИЕм в ИК-дИАпАЗОНЕ / Proydakova, V.Y. [et al.] // Biomedical Photonics. - 2021. - 10. - № 4. - P. 23-34. - 10.24931/2413-9432-2021-10-4-23-34
dc.identifier.doi10.24931/2413-9432-2021-10-4-23-34
dc.identifier.urihttps://www.doi.org/10.24931/2413-9432-2021-10-4-23-34
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85124766394&origin=resultslist
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/25270
dc.relation.ispartofBiomedical Photonics
dc.titleSTUdy OF ENERGy TRANSFER pROCESSES BETWEEN RARE EARTh IONS ANd phOTOSENSITIZER mOLECULES FOR phOTOdyNAmIC ThERApy WITh IR-EXCITATION ИССЛЕдОвАНИЕ пРОЦЕССОв пЕРЕдАчИ ЭНЕРГИИ мЕЖдУ РЕдКОЗЕмЕЛЬНЫмИ ИОНАмИ И мОЛЕКУЛАмИ фОТОСЕНСИБИЛИЗАТОРОв дЛя ЗАдАч фОТОдИНАмИчЕСКОи ТЕРАпИИ С вОЗБУЖдЕНИЕм в ИК-дИАпАЗОНЕ
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue4
oaire.citation.volume10
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