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Boron Nanoparticle-Enhanced Proton Therapy for Cancer Treatment

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dc.contributor.authorZavestovskaya, I. N.
dc.contributor.authorTikhonowski, G. V.
dc.contributor.authorSavinov, M. S.
dc.contributor.authorShakhov, P. V.
dc.contributor.authorBabkova, J. S.
dc.contributor.authorPopov, A. A.
dc.contributor.authorKlimentov, S. M.
dc.contributor.authorPrasad, P. N.
dc.contributor.authorDeyev, S. M.
dc.contributor.authorЗавестовская, Ирина Николаевна
dc.contributor.authorТихоновский, Глеб Валерьевич
dc.contributor.authorСавинов, Максим Сергеевич
dc.contributor.authorШахов, Павел Владимирович
dc.contributor.authorБабкова, Юлия Сергеевна
dc.contributor.authorПопов, Антон Александрович
dc.contributor.authorКлиментов, Сергей Михайлович
dc.contributor.authorДеев, Сергей Михайлович
dc.date.accessioned2024-12-27T08:53:17Z
dc.date.available2024-12-27T08:53:17Z
dc.date.issued2023
dc.description.abstractProton therapy is one of the promising radiotherapy modalities for the treatment of deep-seated and unresectable tumors, and its efficiency can further be enhanced by using boron-containing substances. Here, we explore the use of elemental boron (B) nanoparticles (NPs) as sensitizers for proton therapy enhancement. Prepared by methods of pulsed laser ablation in water, the used B NPs had a mean size of 50 nm, while a subsequent functionalization of the NPs by polyethylene glycol improved their colloidal stability in buffers. Laser-synthesized B NPs were efficiently absorbed by MNNG/Hos human osteosarcoma cells and did not demonstrate any remarkable toxicity effects up to concentrations of 100 ppm, as followed from the results of the MTT and clonogenic assay tests. Then, we assessed the efficiency of B NPs as sensitizers of cancer cell death under irradiation by a 160.5 MeV proton beam. The irradiation of MNNG/Hos cells at a dose of 3 Gy in the presence of 80 and 100 ppm of B NPs led to a 2- and 2.7-fold decrease in the number of formed cell colonies compared to control samples irradiated in the absence of NPs. The obtained data unambiguously evidenced the effect of a strong proton therapy enhancement mediated by B NPs. We also found that the proton beam irradiation of B NPs leads to the generation of reactive oxygen species (ROS), which evidences a possible involvement of the non-nuclear mechanism of cancer cell death related to oxidative stress. Offering a series of advantages, including a passive targeting option and the possibility of additional theranostic functionalities based on the intrinsic properties of B NPs (e.g., photothermal therapy or neutron boron capture therapy), the proposed concept promises a major advancement in proton beam-based cancer treatment.
dc.identifier.citationBoron Nanoparticle-Enhanced Proton Therapy for Cancer Treatment / Zavestovskaya, I. N. [et al.] // Nanomaterials. - 2023. - 13. - № 15. - 10.3390/nano13152167
dc.identifier.doi10.3390/nano13152167
dc.identifier.urihttps://www.doi.org/10.3390/nano13152167
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85167673092&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:001045573600001
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/29152
dc.relation.ispartofNanomaterials
dc.subjectClonogenic assay
dc.subjectMetal Nanoparticles
dc.subjectMTT assay
dc.titleBoron Nanoparticle-Enhanced Proton Therapy for Cancer Treatment
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue15
oaire.citation.volume13
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