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Nanoparticle-based drug delivery: Via RBC-hitchhiking for the inhibition of lung metastases growth

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dc.contributor.authorYaremenko, A. V.
dc.contributor.authorBabenyshev, A. V.
dc.contributor.authorBalalaeva, I. V.
dc.contributor.authorNikitin, M. P.
dc.contributor.authorZelepukin, I. V.
dc.contributor.authorShipunova, V. O.
dc.contributor.authorNikitin, P. I.
dc.contributor.authorDeyev, S. M.
dc.contributor.authorНикитин, Петр Иванович
dc.contributor.authorДеев, Сергей Михайлович
dc.date.accessioned2024-11-20T09:21:32Z
dc.date.available2024-11-20T09:21:32Z
dc.date.issued2019
dc.description.abstract© The Royal Society of Chemistry. Delivery of particle-based theranostic agents via their transportation on the surfaces of red blood cells, commonly referred to as RBC-hitchhiking, has historically been developed as a promising strategy for increasing the extremely poor blood circulation lifetime, primarily, of the large-sized sub-micron agents. Here, we show for the first time that RBC-hitchhiking can be extremely efficient for nanoparticle delivery and tumor treatment even in those cases when no circulation prolongation is observed. Specifically, we demonstrate that RBC-hitchhiking of certain small 100 nm particles, unlike that of the conventional sub-micron ones, can boost the delivery of non-targeted particles to lungs up to a record high value of 120-fold (and up to 40% of the injected dose). To achieve this remarkable result, we screened sub-200 nm nanoparticles of different sizes, polymer coatings and ζ-potentials and identified particles with the optimal RBC adsorption/desorption behavior. Furthermore, we demonstrated that such RBC-mediated rerouting of particles to lungs can be used to fight pulmonary metastases of aggressive melanoma B16-F1. Our findings could change the general paradigm of drug delivery for cancer treatment with RBC-hitchhiking. It is not the blood circulation lifetime that is the key factor for nanoparticle efficiency, but rather the complexation of nanoparticles with the RBC. The demonstrated technology could become a valuable tool for development of new strategies based on small nanoparticles for the treatment of aggressive and small-cell types of cancer as well as other lung diseases.
dc.format.extentС. 1636-1646
dc.identifier.citationNanoparticle-based drug delivery: Via RBC-hitchhiking for the inhibition of lung metastases growth / Yaremenko, A.V. [et al.] // Nanoscale. - 2019. - 11. - № 4. - P. 1636-1646. - 10.1039/c8nr07730d
dc.identifier.doi10.1039/c8nr07730d
dc.identifier.urihttps://www.doi.org/10.1039/c8nr07730d
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85060329925&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000459910900013
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/16472
dc.relation.ispartofNanoscale
dc.titleNanoparticle-based drug delivery: Via RBC-hitchhiking for the inhibition of lung metastases growth
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue4
oaire.citation.volume11
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