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Laser-ablative synthesis of stable aqueous solutions of elemental bismuth nanoparticles for multimodal theranostic applications

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dc.contributor.authorBulmahn, J. C.
dc.contributor.authorKuzmin, A.
dc.contributor.authorTikhonowski, G.
dc.contributor.authorPopov, A. A.
dc.contributor.authorKlimentov, S. M.
dc.contributor.authorKabashin, A. V.
dc.contributor.authorPrasad, P. N.
dc.contributor.authorТихоновский, Глеб Валерьевич
dc.contributor.authorПопов, Антон Александрович
dc.contributor.authorКлиментов, Сергей Михайлович
dc.contributor.authorКабашин, Андрей Викторович
dc.date.accessioned2024-11-27T07:44:25Z
dc.date.available2024-11-27T07:44:25Z
dc.date.issued2020
dc.description.abstract© 2020 by the authors. Licensee MDPI, Basel, Switzerland.Elemental bismuth (Bi) nanoparticles (NPs), with the high atomic density of the Bi nuclei, could serve as efficient targeted agents for cancer treatment, with applications such as contrast agents for computed tomography (CT) imaging, sensitizers for image-guided X-ray radiotherapy, and photothermal therapy. However, the synthesis of elemental Bi NPs suitable for biological applications is difficult using conventional chemical routes. Here, we explore the fabrication of ultrapure Bi-based nanomaterials by femtosecond laser ablation from a solid Bi target in ambient liquids and characterize them by a variety of techniques, including TEM, SEM, XRD, FTIR, Raman, and optical spectroscopy. We found that laser-ablative synthesis using an elemental Bi solid target leads to the formation of spherical Bi NPs having the mean size of 20–50 nm and a low size-dispersion. The NPs prepared in water experience a fast (within a few minutes) conversion into 400–500 nm flake-like nanosheets, composed of bismuth subcarbonates, (BiO)2 CO3 and (BiO)4 CO3 (OH)2, while the NPs prepared in acetone demonstrate high elemental stability. We introduce a procedure to obtain a stable aqueous solution of elemental Bi NPs suitable for biological applications, based on the coating of Bi NPs prepared in acetone with Pluronic® F68 and their subsequent transfer to water. We also show that the laser-synthesized elemental Bi NPs, due to their vanishing band gap, exhibit remarkable absorption in the infrared range, which can be used for the activation of photothermal therapy in the near IR-to-IR window with maximum optical transparency in biological media. Exempt of any toxic synthetic by-products, laser-ablated elemental Bi NPs present a novel appealing nanoplatform for combination image-guided photoradiotherapies.
dc.format.extentС. 1-13
dc.identifier.citationLaser-ablative synthesis of stable aqueous solutions of elemental bismuth nanoparticles for multimodal theranostic applications / Bulmahn, J.C. [et al.] // Nanomaterials. - 2020. - 10. - № 8. - P. 1-13. - 10.3390/nano10081463
dc.identifier.doi10.3390/nano10081463
dc.identifier.urihttps://www.doi.org/10.3390/nano10081463
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85090676718&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000564612000001
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/22308
dc.relation.ispartofNanomaterials
dc.titleLaser-ablative synthesis of stable aqueous solutions of elemental bismuth nanoparticles for multimodal theranostic applications
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue8
oaire.citation.volume10
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