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Comparison of pharmacokinetics and biodistribution of laser-synthesized plasmonic Au and TiN nanoparticles

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dc.contributor.authorTselikov, G. I.
dc.contributor.authorAl-Kattan, A.
dc.contributor.authorBailly, A. -L.
dc.contributor.authorCorreard, F.
dc.contributor.authorPopov, A. A.
dc.contributor.authorZelepukin, I. V.
dc.contributor.authorTikhonowski, G. V.
dc.contributor.authorPopova-Kuznetsova, E. A.
dc.contributor.authorKlimentov, S. M.
dc.contributor.authorDeyev, S. M.
dc.contributor.authorKabashin, A. V.
dc.contributor.authorПопов, Антон Александрович
dc.contributor.authorТихоновский, Глеб Валерьевич
dc.contributor.authorПопова-Кузнецова, Елена Алефтиновна
dc.contributor.authorКлиментов, Сергей Михайлович
dc.contributor.authorДеев, Сергей Михайлович
dc.contributor.authorКабашин, Андрей Викторович
dc.date.accessioned2024-11-29T23:17:54Z
dc.date.available2024-11-29T23:17:54Z
dc.date.issued2021
dc.description.abstract© 2021 Institute of Physics Publishing. All rights reserved.Plasmonic nanostructures offer wide range of diagnostic and therapeutic functionalities for biomedical applications. Gold nanoparticles (Au NPs) present one of the most explored nanomaterial in this field, while titanium nitride nanoparticles (TiN NPs) is a new promising nanomaterial with superior plasmonic properties for biomedicine. However conventional chemical techniques for the synthesis of these nanomaterials cannot always match stringent requirements for toxicity levels and surface conditioning. Laser-synthesized Au and TiN NPs offer exceptional purity (no contamination by by-products or ligands) and unusual surface chemistry. Therefore, these NPs present a viable alternative to chemically synthesized counterparts. This work presents comparative analysis of pharmacokinetics and biodistribution of laser-synthesized 20 nm Au and TiN NPs under intravenous administration in mice model. Our data show that Au NPs and bare TiN NPs are rapidly eliminated from the blood circulation and accumulate preferentially in liver and spleen, while coating of TiN NPs by hydrophilic polymer polyethylene glycol (PEG) significantly prolongates blood circulation time and improves delivery of the NPs to tumor. We finally discuss potential applications of laser synthesized Au NPs in SERS, SEIRA and electrocatalysis, while TiN nanoparticles are considered as promising agents for photothermal therapy and photoacoustic imaging.
dc.identifier.citationComparison of pharmacokinetics and biodistribution of laser-synthesized plasmonic Au and TiN nanoparticles / Tselikov, G.I. [et al.] // Journal of Physics: Conference Series. - 2021. - 2058. - № 1. - 10.1088/1742-6596/2058/1/012004
dc.identifier.doi10.1088/1742-6596/2058/1/012004
dc.identifier.urihttps://www.doi.org/10.1088/1742-6596/2058/1/012004
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85119524849&origin=resultslist
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/24977
dc.relation.ispartofJournal of Physics: Conference Series
dc.titleComparison of pharmacokinetics and biodistribution of laser-synthesized plasmonic Au and TiN nanoparticles
dc.typeConference Paper
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume2058
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