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Conjugates of ultrasmall quantum dots and acridine derivatives as prospective nanoprobes for intracellular investigations

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dc.contributor.authorLaronze-Cochard, M.
dc.contributor.authorSapi, J.
dc.contributor.authorKaraulov, A.
dc.contributor.authorLinkov, P.
dc.contributor.authorSamokhvalov, P.
dc.contributor.authorBaryshnikova, M.
dc.contributor.authorNabiev, I.
dc.contributor.authorСамохвалов, Павел Сергеевич
dc.contributor.authorБарышникова, Мария Анатольевна
dc.contributor.authorНабиев, Игорь Руфаилович
dc.date.accessioned2024-11-29T19:44:01Z
dc.date.available2024-11-29T19:44:01Z
dc.date.issued2021
dc.description.abstract© 2021 by the authors. Licensee MDPI, Basel, Switzerland.Designing nanoprobes in which quantum dots (QDs) are used as photoluminescent labels is an especially promising line of research due to their possible medical applications ranging from disease diagnosis to drug delivery. In spite of the significant progress made in designing such nanoprobes, the properties of their individual components, i.e., photoluminescent QDs, vectorization moieties, and pharmacological agents, still require further optimization to enhance the efficiency of diagnostic or therapeutic procedures. Here, we have developed a method of engineering compact multifunctional nanoprobes based on functional components with optimized properties: bright photoluminescence of CdSe/ZnS (core/shell) QDs, a compact and effective antitumor agent (an acridine derivative), and direct conjugation of the components via electrostatic interaction, which provides a final hydrodynamic diameter of nanoprobes smaller than 15 nm. Due to the possibility of conjugating various biomolecules with hydroxyl and carboxyl moieties to QDs, the method represents a versatile approach to the biomarker-recognizing molecule imaging of the delivery of the active substance as part of compact nanoprobes.
dc.identifier.citationConjugates of ultrasmall quantum dots and acridine derivatives as prospective nanoprobes for intracellular investigations / Laronze-Cochard, M. [et al.] // Nanomaterials. - 2021. - 11. - № 9. - 10.3390/nano11092160
dc.identifier.doi10.3390/nano11092160
dc.identifier.urihttps://www.doi.org/10.3390/nano11092160
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85113758607&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000701405300001
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/24623
dc.relation.ispartofNanomaterials
dc.titleConjugates of ultrasmall quantum dots and acridine derivatives as prospective nanoprobes for intracellular investigations
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue9
oaire.citation.volume11
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