Publication:
Antitumor activity of photodynamic therapy with tetracationic derivative of synthetic bacteriochlorin in spheroid culture of liver and colon cancer cells

Простая страница элемента
dc.contributor.authorKarshieva, S. S.
dc.contributor.authorGlinskaya, E. G.
dc.contributor.authorDalina, A. A.
dc.contributor.authorAkhlyustina, E. V.
dc.contributor.authorMironov, V. A.
dc.contributor.authorMeerovich, G. A.
dc.contributor.authorKogan, E. A.
dc.contributor.authorKoudan, E. V.
dc.contributor.authorАхлюстина, Екатерина Витальевна
dc.contributor.authorМиронов, Владимир Александрович
dc.contributor.authorМеерович, Геннадий Александрович
dc.contributor.authorКудан, Елизавета Валерьевна
dc.date.accessioned2024-12-25T10:57:58Z
dc.date.available2024-12-25T10:57:58Z
dc.date.issued2022
dc.description.abstractEfficient screening of photosensitizers (PS) as well as studying their photodynamic activity, especially PS excited in the near-infrared region, require informative in vitro models to adequately reflect the architecture, thickness, and intercellular interactions in tumors. In our study, we used spheroids formed from human colon cancer HCT-116 cells and liver cancer Huh7 cells to assess the phototoxicity of a new PS based on tetracationic derivative of synthetic bacteriochlorin (BC4). We optimized conditions for the irradiation regime based on the kinetics of BC4 accumulation in spheroids and kinetics of spheroid growth. Although PS accumulated more efficiently in HCT-116 cells, characterized by more aggressive growth and high proliferative potential, they were less susceptible to the photodynamic therapy (PDT) compared to the slower growing Huh7 cells. We also showed that 3D models of spheroids were less sensitive to BC4 than conventional 2D cultures with relatively identical kinetics of drug accumulation. Our findings suggest that BC4 is a perspective agent for photodynamic therapy against cancer cells. Copyright © 2022 Elsevier B.V. All rights reserved.
dc.format.extentС. 103202
dc.identifier.citationAntitumor activity of photodynamic therapy with tetracationic derivative of synthetic bacteriochlorin in spheroid culture of liver and colon cancer cells / Karshieva, S.S. [et al.] // Photodiagnosis and photodynamic therapy. - 2022. - 40. - P. 103202. - 10.1016/j.pdpdt.2022.103202
dc.identifier.doi10.1016/j.pdpdt.2022.103202
dc.identifier.urihttps://www.doi.org/10.1016/j.pdpdt.2022.103202
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85143916901&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000897793200007
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/27697
dc.relation.ispartofPhotodiagnosis and photodynamic therapy
dc.subjectCytotoxicity
dc.subjectPhotodynamic therapy
dc.subjectPhotosensitizer
dc.subjectPhototoxicity
dc.subjectTetracationic bacteriochlorin
dc.subjectThree-dimensional spheroid culture
dc.titleAntitumor activity of photodynamic therapy with tetracationic derivative of synthetic bacteriochlorin in spheroid culture of liver and colon cancer cells
dc.typeArticle
dspace.entity.typePublication
oaire.citation.volume40
relation.isAuthorOfPublicationa5945d1a-3333-4471-a016-b540d23cf671
relation.isAuthorOfPublication25d65074-da93-47bb-89dd-b1420c2aab5b
relation.isAuthorOfPublication2502d1f4-258a-4f5a-9d2f-90901b35ed2f
relation.isAuthorOfPublication159432c7-a13b-4998-998d-51018a75b3ef
relation.isAuthorOfPublication.latestForDiscoverya5945d1a-3333-4471-a016-b540d23cf671
relation.isOrgUnitOfPublicationc8407a6f-7272-450d-8d99-032352c76b55
relation.isOrgUnitOfPublication.latestForDiscoveryc8407a6f-7272-450d-8d99-032352c76b55
Файлы
Коллекции
Публикации