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Fast processes of nanoparticle blood clearance: Comprehensive study

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dc.contributor.authorYaremenko, A. V.
dc.contributor.authorYuryev, M. V.
dc.contributor.authorMirkasymov, A. B.
dc.contributor.authorSokolov, I. L.
dc.contributor.authorZelepukin, I. V.
dc.contributor.authorDeyev, S. M.
dc.contributor.authorNikitin, P. I.
dc.contributor.authorДеев, Сергей Михайлович
dc.contributor.authorНикитин, Петр Иванович
dc.date.accessioned2024-11-26T15:06:40Z
dc.date.available2024-11-26T15:06:40Z
dc.date.issued2020
dc.description.abstract© 2020 Elsevier B.V.Blood circulation is the key parameter that determines the in vivo efficiency of nanoagents. Despite clinical success of the stealth liposomal agents with their inert and shielded surfaces, a great number of non-stealth nanomaterials is being developed due to their potential of enhanced functionality. By harnessing surface phenomena, such agents can offer advanced control over drug release through intricately designed nanopores, catalysis-propelled motion, computer-like analysis of several disease markers for precise target identification, etc. However, investigation of pharmacokinetic behavior of these agents becomes a great challenge due to ultra-short circulation (usually around several minutes) and impossibility to use the invasive blood-sampling techniques. Accordingly, the data on circulation of such agents has been scarce and irregular. Here, we demonstrate high-throughput capabilities of the developed magnetic particle quantification technique for nanoparticle circulation measurements and present a comprehensive investigation of factors that affect blood circulation of the non-stealth nanoparticles. Namely, we studied the following 9 factors: particle size, zeta-potential, coating, injection dose, repetitive administration, induction of anesthesia, mice strain, absence/presence of tumors, tumor size. Our fundamental findings demonstrate potential ways to extend the half-life of the agents in blood thereby giving them a better chance of achieving their goal in the organism. The study will be valuable for design of the next generation nanomaterials with advanced biomedical functionality.
dc.format.extentС. 181-191
dc.identifier.citationFast processes of nanoparticle blood clearance: Comprehensive study / Yaremenko, A.V. [et al.] // Journal of Controlled Release. - 2020. - 326. - P. 181-191. - 10.1016/j.jconrel.2020.07.014
dc.identifier.doi10.1016/j.jconrel.2020.07.014
dc.identifier.urihttps://www.doi.org/10.1016/j.jconrel.2020.07.014
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85088240879&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000572083700008
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/22062
dc.relation.ispartofJournal of Controlled Release
dc.titleFast processes of nanoparticle blood clearance: Comprehensive study
dc.typeArticle
dspace.entity.typePublication
oaire.citation.volume326
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