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Terahertz technology in diagnosis of glioma molecular markers

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dc.contributor.authorKuznetsov, S.
dc.contributor.authorKonnikova, M.
dc.contributor.authorHeinz, T.
dc.contributor.authorDizer, E.
dc.contributor.authorNikolaev, N.
dc.contributor.authorUtkin, D.
dc.contributor.authorCherkasova, O.
dc.date.accessioned2024-12-25T09:41:47Z
dc.date.available2024-12-25T09:41:47Z
dc.date.issued2022
dc.description.abstractAbstract Gliomas are invasive brain tumors with high rates of recurrence and mortality. It has been shown that specific markers for glioma’s differential diagnostics are enantiomers of 2-hydroxyglutarate (L-2HG and D-2HG) in brain tissues and blood. These isomers have unique absorption peaks originating from vibrational and rotational transitions in their molecules. In particular, the peaks centered at 1.337 THz and 1.695 THz correspond to L-2HG and D-2HG isomers, respectively. The goal of this work is to develop highly efficient frequency-selective sensors for L-2HG and D-2HG isomers using the effect of nanoantenna-assisted plasmonic enhancement of THz absorption. Such an approach provides a noticeable increase in detection sensitivity versus direct non-resonant methods. In this paper, we present the numerical results of the design optimization for L-2HG and D-2HG sensors based on Si/SiO 2 -wafer-backed arrays of golden nanoantennas of linear geometry. The optimal structural parameters of the arrays found through integral averaging of the square of the surface electric field over an array unit cell are recommended for further nanolithographic fabrication of this kind of THz sensor.
dc.identifier.citationTerahertz technology in diagnosis of glioma molecular markers / Kuznetsov, S. [et al.] // Journal of Physics: Conference Series. - 2022. - 2316. - № 1. - 10.1088/1742-6596/2316/1/012016
dc.identifier.doi10.1088/1742-6596/2316/1/012016
dc.identifier.urihttps://www.doi.org/10.1088/1742-6596/2316/1/012016
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85138256372&origin=resultslist
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/27556
dc.relation.ispartofJournal of Physics: Conference Series
dc.titleTerahertz technology in diagnosis of glioma molecular markers
dc.typeConference Paper
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume2316
relation.isOrgUnitOfPublication06e1796d-4f55-4057-8d7e-bb2f3b5676f5
relation.isOrgUnitOfPublication.latestForDiscovery06e1796d-4f55-4057-8d7e-bb2f3b5676f5
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