Publication:
Novel polycationic photosensitizers for antibacterial photodynamic therapy

Простая страница элемента
dc.contributor.authorTiganova, I. G.
dc.contributor.authorLukyanets, E. A.
dc.contributor.authorMakarova, E. A.
dc.contributor.authorTolordava, E. R.
dc.contributor.authorMeerovich, G. A.
dc.contributor.authorAkhlyustina, E. V.
dc.contributor.authorLoschenov, V. B.
dc.contributor.authorМеерович, Геннадий Александрович
dc.contributor.authorАхлюстина, Екатерина Витальевна
dc.contributor.authorЛощенов, Виктор Борисович
dc.date.accessioned2024-11-27T17:11:15Z
dc.date.available2024-11-27T17:11:15Z
dc.date.issued2020
dc.description.abstract© Springer Nature Switzerland AG 2019.Antibacterial photodynamic therapy (APDT) is a promising method of treating local infected foci, in particular, surgical and burn wounds, trophic and diabetic ulcers. Photodynamic inactivation (PDI) is able to effectively destroy bacterial cells without them developing resistance in response to treatment. This work was dedicated to the study of photophysical and antibacterial properties of new photosensitizers (PS) based on polycationic phthalocyanines and synthetic bacteriochlorins for photodynamic inactivation of P. aeruginosa bacteria and their biofilms. Gram-negative bacteria P. aeruginosa are often found in infected wounds, presumably in biofilm state and are characterized by rather low susceptibility to APDT, which is a problem. PS were studied for possible aggregation at various concentrations by means of absorption and fluorescence spectroscopy. The results of studies of the ZnPcChol8, (3-PyHp)4BCBr4 and (3-PyEBr)4BCBr4 in water and serum confirm the assumption of a low degree of their aggregation at high concentrations. Consequently, their photodynamic efficiency is high enabling to use these PS at high concentrations to sensitize pathological foci for APDT. It was shown that all the investigated PS had a high efficiency of photodynamic inactivation of Gram-negative bacteria P. aeruginosa, as well as their biofilms. Tetracationic hydrophilic near-infrared photosensitizer (3-PyEBr)4BCBr4 with reduced molecule size had significantly higher efficacy of photodynamic inactivation of P. aeruginosa biofilms compared with other studied photosensitizers.
dc.format.extentС. 1-19
dc.identifier.citationNovel polycationic photosensitizers for antibacterial photodynamic therapy / Tiganova, I.G. [et al.] // Advances in Experimental Medicine and Biology. - 2020. - 1282. - P. 1-19. - 10.1007/5584_2019_431
dc.identifier.doi10.1007/5584_2019_431
dc.identifier.urihttps://www.doi.org/10.1007/5584_2019_431
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85083172716&origin=resultslist
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/23218
dc.relation.ispartofAdvances in Experimental Medicine and Biology
dc.titleNovel polycationic photosensitizers for antibacterial photodynamic therapy
dc.typeBook Chapter
dspace.entity.typePublication
oaire.citation.volume1282
relation.isAuthorOfPublication2502d1f4-258a-4f5a-9d2f-90901b35ed2f
relation.isAuthorOfPublicationa5945d1a-3333-4471-a016-b540d23cf671
relation.isAuthorOfPublication371640a5-5007-444c-a657-ccfac33ccebd
relation.isAuthorOfPublication.latestForDiscovery2502d1f4-258a-4f5a-9d2f-90901b35ed2f
relation.isOrgUnitOfPublicationc8407a6f-7272-450d-8d99-032352c76b55
relation.isOrgUnitOfPublication.latestForDiscoveryc8407a6f-7272-450d-8d99-032352c76b55
Файлы
Коллекции
Публикации