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Laser-Synthesized Elemental Boron Nanoparticles for Efficient Boron Neutron Capture Therapy

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dc.contributor.authorZavestovskaya, I. N.
dc.contributor.authorZavestovskaya,I.N.
dc.contributor.authorBabkova, J. S.
dc.contributor.authorZelepukin, I. V.
dc.contributor.authorTikhonowski, G. V.
dc.contributor.authorPopov, A. A.
dc.contributor.authorKlimentov, S. M.
dc.contributor.authorЗавестовская, Ирина Николаевна
dc.contributor.authorБабкова, Юлия Сергеевна
dc.contributor.authorТихоновский, Глеб Валерьевич
dc.contributor.authorПопов, Антон Александрович
dc.contributor.authorКлиментов, Сергей Михайлович
dc.contributor.authorДеев, Сергей Михайлович
dc.date.accessioned2024-12-27T12:19:09Z
dc.date.available2024-12-27T12:19:09Z
dc.date.issued2023
dc.description.abstractBoron neutron capture therapy (BNCT) is one of the most appealing radiotherapy modalities, whose localization can be further improved by the employment of boron-containing nanoformulations, but the fabrication of biologically friendly, water-dispersible nanoparticles (NPs) with high boron content and favorable physicochemical characteristics still presents a great challenge. Here, we explore the use of elemental boron (B) NPs (BNPs) fabricated using the methods of pulsed laser ablation in liquids as sensitizers of BNCT. Depending on the conditions of laser-ablative synthesis, the used NPs were amorphous (a-BNPs) or partially crystallized (pc-BNPs) with a mean size of 20 nm or 50 nm, respectively. Both types of BNPs were functionalized with polyethylene glycol polymer to improve colloidal stability and biocompatibility. The NPs did not initiate any toxicity effects up to concentrations of 500 Вµg/mL, based on the results of MTT and clonogenic assay tests. The cells with BNPs incubated at a 10B concentration of 40 Вµg/mL were then irradiated with a thermal neutron beam for 30 min. We found that the presence of BNPs led to a radical enhancement in cancer cell death, namely a drop in colony forming capacity of SW-620 cells down to 12.6% and 1.6% for a-BNPs and pc-BNPs, respectively, while the relevant colony-forming capacity for U87 cells dropped down to 17%. The effect of cell irradiation by neutron beam uniquely was negligible under these conditions. Finally, to estimate the dose and regimes of irradiation for future BNCT in vivo tests, we studied the biodistribution of boron under intratumoral administration of BNPs in immunodeficient SCID mice and recorded excellent retention of boron in tumors. The obtained data unambiguously evidenced the effect of a neutron therapy enhancement, which can be attributed to efficient BNP-mediated generation of О±-particles.
dc.identifier.citationLaser-Synthesized Elemental Boron Nanoparticles for Efficient Boron Neutron Capture Therapy / Zavestovskaya, I. N. [et al.] // International Journal of Molecular Sciences. - 2023. - 24. - № 23. - 10.3390/ijms242317088
dc.identifier.doi10.3390/ijms242317088
dc.identifier.urihttps://www.doi.org/10.3390/ijms242317088
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85179313296&origin=resultslist
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/29518
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.subjectBoron Neutron Capture Therapy
dc.subjectNeutron capture
dc.subjectLaser Ablation
dc.subjectBiocompatibility
dc.subjectBoric acid
dc.titleLaser-Synthesized Elemental Boron Nanoparticles for Efficient Boron Neutron Capture Therapy
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue23
oaire.citation.volume24
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