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Nanophotonic tools based on the conjugates of nanoparticles with the single-domain antibodies for multi-photon micrometastases detection and ultrasensitive biochemical assays

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dc.contributor.authorRamos-Gomes, F.
dc.contributor.authorChames, P.
dc.contributor.authorBaty, D.
dc.contributor.authorAlves, F.
dc.contributor.authorSukhanova, A.
dc.contributor.authorSamokhvalov, P.
dc.contributor.authorNabiev, I.
dc.contributor.authorСуханова, Алена Владимировна
dc.contributor.authorСамохвалов, Павел Сергеевич
dc.contributor.authorНабиев, Игорь Руфаилович
dc.date.accessioned2024-11-22T06:55:28Z
dc.date.available2024-11-22T06:55:28Z
dc.date.issued2019
dc.description.abstract© 2019 SPIE.Semiconductor quantum dots (QDs) are characterized by orders of magnitude higher multiphoton linear absorption cross-sections compared with conventional organic dyes. Combined with the QD photoluminescence quantum yield approaching 100%, this fact opens great prospects for the twophoton functional tumor imaging with QDs tagged with highly specific recognition molecules. Single-domain antibodies (sdAbs) or "nanobodies" derived from lamas are the smallest high-affinity recognition molecules, which may be tagged with the QDs thus permitting not only solid tumors multiphoton imaging but also rare disseminated cancer cells and micrometastases in the depth of the tissue to be detected. Additionally, unique photostability of QDs enables signal accumulation and significant enhancement of the sensitivity of routine biochemical and immunohistochemical assays to be obtained when the conjugates of QDs, instead of organic dyes, are used.
dc.identifier.citationNanophotonic tools based on the conjugates of nanoparticles with the single-domain antibodies for multi-photon micrometastases detection and ultrasensitive biochemical assays / Ramos-Gomes, F. [et al.] // Proceedings of SPIE - The International Society for Optical Engineering. - 2019. - 11207. - 10.1117/12.2530233
dc.identifier.doi10.1117/12.2530233
dc.identifier.urihttps://www.doi.org/10.1117/12.2530233
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85074258953&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000535234000082
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/19747
dc.relation.ispartofProceedings of SPIE - The International Society for Optical Engineering
dc.titleNanophotonic tools based on the conjugates of nanoparticles with the single-domain antibodies for multi-photon micrometastases detection and ultrasensitive biochemical assays
dc.typeConference Paper
dspace.entity.typePublication
oaire.citation.volume11207
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