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High resolution 3D visualization of the spinal cord in a post-mortem murine model

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dc.contributor.authorBukreeva, I.
dc.contributor.authorAsadchikov, V.
dc.contributor.authorBuzmakov, A.
dc.contributor.authorChukalina, M.
dc.contributor.authorKorolev, N. A.
dc.contributor.authorКоролев, Николай Анатольевич
dc.date.accessioned2024-11-25T17:38:24Z
dc.date.available2024-11-25T17:38:24Z
dc.date.issued2020
dc.description.abstract© 2020 Optical Society of America under the terms of the OSA Open Access Publishing AgreementA crucial issue in the development of therapies to treat pathologies of the central nervous system is represented by the availability of non-invasive methods to study the three-dimensional morphology of spinal cord, with a resolution able to characterize its complex vascular and neuronal organization. X-ray phase contrast micro-tomography enables a high-quality, 3D visualization of both the vascular and neuronal network simultaneously without the need of contrast agents, destructive sample preparations or sectioning. Until now, high resolution investigations of the post-mortem spinal cord in murine models have mostly been performed in spinal cords removed from the spinal canal. We present here post-mortem phase contrast micro-tomography images reconstructed using advanced computational tools to obtain high-resolution and high-contrast 3D images of the fixed spinal cord without removing the bones and preserving the richness of micro-details available when measuring exposed spinal cords. We believe that it represents a significant step toward the in-vivo application.
dc.format.extentС. 2235-2253
dc.identifier.citationHigh resolution 3D visualization of the spinal cord in a post-mortem murine model / Bukreeva, I. [et al.] // Biomedical Optics Express. - 2020. - 11. - № 4. - P. 2235-2253. - 10.1364/BOE.386837
dc.identifier.doi10.1364/BOE.386837
dc.identifier.urihttps://www.doi.org/10.1364/BOE.386837
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85082755016&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000523980200039
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/20501
dc.relation.ispartofBiomedical Optics Express
dc.titleHigh resolution 3D visualization of the spinal cord in a post-mortem murine model
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue4
oaire.citation.volume11
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