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In vivo blockade of mononuclear phagocyte system with solid nanoparticles: Efficiency and affecting factors

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dc.contributor.authorMirkasymov, A. B.
dc.contributor.authorNikitin, M. P.
dc.contributor.authorZelepukin, I. V.
dc.contributor.authorNikitin, P. I.
dc.contributor.authorDeyev, S. M.
dc.contributor.authorНикитин, Петр Иванович
dc.contributor.authorДеев, Сергей Михайлович
dc.date.accessioned2024-11-29T10:39:47Z
dc.date.available2024-11-29T10:39:47Z
dc.date.issued2021
dc.description.abstract© 2020 Elsevier B.V.Smart nanomaterials, contrast nanoparticles and drug nanocarriers of advanced targeting architecture were designed for various biomedical applications. Most of such agents demonstrate poor pharmacokinetics in vivo due to rapid elimination from the bloodstream by cells of the mononuclear phagocyte system (MPS). One of the promising methods to prolong blood circulation of the nanoparticles without their modification is MPS blockade. The method temporarily decreases macrophage endocytosis in response to uptake of a low-toxic non-functional material. The effect of different factors on the efficiency of macrophage blockade in vivo induced by solid nanomaterials has been studied here. Those include: blocker nanoparticle size, ζ-potential, surface coating, dose, mice strain, presence of tumor or inflammation. We found that the blocker particle coating type had the strongest effect on MPS blockade efficiency, which allowed to prolong functional particle blood circulation half-life 18 times. The mechanisms capable of regulation of the MPS blockade have been demonstrated, which can promote application of this phenomenon in medicine for improving delivery of diagnostic and therapeutic nanomaterials.
dc.format.extentС. 111-118
dc.identifier.citationIn vivo blockade of mononuclear phagocyte system with solid nanoparticles: Efficiency and affecting factors / Mirkasymov, A.B. [et al.] // Journal of Controlled Release. - 2021. - 330. - P. 111-118. - 10.1016/j.jconrel.2020.12.004
dc.identifier.doi10.1016/j.jconrel.2020.12.004
dc.identifier.urihttps://www.doi.org/10.1016/j.jconrel.2020.12.004
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85098178151&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000626459100009
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/23502
dc.relation.ispartofJournal of Controlled Release
dc.titleIn vivo blockade of mononuclear phagocyte system with solid nanoparticles: Efficiency and affecting factors
dc.typeArticle
dspace.entity.typePublication
oaire.citation.volume330
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