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Fabrication of stable nanofiber matrices for tissue engineering via electrospinning of bare laser-synthesized au nanoparticles in solutions of high molecular weight chitosan

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dc.contributor.authorNirwan, V. P.
dc.contributor.authorAl-Kattan, A.
dc.contributor.authorFahmi, A.
dc.contributor.authorKabashin, A. V.
dc.contributor.authorКабашин, Андрей Викторович
dc.date.accessioned2024-11-21T11:07:18Z
dc.date.available2024-11-21T11:07:18Z
dc.date.issued2019
dc.description.abstract© 2019 by the authors. Licensee MDPI, Basel, Switzerland.We report a methodology for the fabrication of neutralized chitosan-based nanofiber matrices decorated with bare Au nanoparticles, which demonstrate stable characteristics even after prolonged contact with a biological environment. The methodology consists of electrospinning of a mixture of bare (ligand-free) laser-synthesized Au nanoparticles (AuNPs) and solutions of chitosan/polyethylene oxide (ratio 1/3) containing chitosan of a relatively high molecular weight (200 kDa) and concentration of 3% (w/v). Our studies reveal a continuous morphology of hybrid nanofibers with the mean fiber diameter of 189 nm ± 86 nm, which demonstrate a high thermal stability. Finally, we describe a protocol for the neutralization of nanofibers, which enabled us to achieve their structural stability in phosphate-buffered saline (PBS) for more than six months, as confirmed by microscopy and FTIR measurements. The formed hybrid nanofibers exhibit unique physicochemical properties essential for the development of future tissue engineering platforms.
dc.identifier.citationFabrication of stable nanofiber matrices for tissue engineering via electrospinning of bare laser-synthesized au nanoparticles in solutions of high molecular weight chitosan / Nirwan, V.P. [et al.] // Nanomaterials. - 2019. - 9. - № 8. - 10.3390/nano9081058
dc.identifier.doi10.3390/nano9081058
dc.identifier.urihttps://www.doi.org/10.3390/nano9081058
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85070397447&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000483604500003
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/18554
dc.relation.ispartofNanomaterials
dc.titleFabrication of stable nanofiber matrices for tissue engineering via electrospinning of bare laser-synthesized au nanoparticles in solutions of high molecular weight chitosan
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue8
oaire.citation.volume9
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relation.isAuthorOfPublication.latestForDiscoveryb79a080b-900d-4655-ba2e-53fd552b3a15
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