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Gene-Activated Materials in Regenerative Dentistry: Narrative Review of Technology and Study Results

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dc.contributor.authorKrasilnikova, O.
dc.contributor.authorYakimova, A.
dc.contributor.authorIvanov, S.
dc.contributor.authorAtiakshin, D.
dc.contributor.authorKlabukov, I. D.
dc.date.accessioned2024-12-27T11:55:35Z
dc.date.available2024-12-27T11:55:35Z
dc.date.issued2023
dc.description.abstractTreatment of a wide variety of defects in the oral and maxillofacial regions requires the use of innovative approaches to achieve best outcomes. One of the promising directions is the use of gene-activated materials (GAMs) that represent a combination of tissue engineering and gene therapy. This approach implies that biocompatible materials will be enriched with gene-carrying vectors and implanted into the defect site resulting in transfection of the recipient’s cells and secretion of encoded therapeutic protein in situ. GAMs may be presented in various designs depending on the type of material, encoded protein, vector, and way of connecting the vector and the material. Thus, it is possible to choose the most suitable GAM design for the treatment of a particular pathology. The use of plasmids for delivery of therapeutic genes is of particular interest. In the present review, we aimed to delineate the principle of work and various designs of plasmid-based GAMs and to highlight results of experimental and clinical studies devoted to the treatment of periodontitis, jaw bone defects, teeth avulsion, and other pathologies in the oral and maxillofacial regions.
dc.identifier.citationGene-Activated Materials in Regenerative Dentistry: Narrative Review of Technology and Study Results / Krasilnikova, O. [et al.] // International Journal of Molecular Sciences. - 2023. - 24. - № 22. - 10.3390/ijms242216250
dc.identifier.doi10.3390/ijms242216250
dc.identifier.urihttps://www.doi.org/10.3390/ijms242216250
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85177754732&origin=resultslist
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/29483
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.subjectBiocompatible material
dc.subjectRegenerative medicine
dc.subjectNarrative review
dc.subjectBone Regeneration
dc.titleGene-Activated Materials in Regenerative Dentistry: Narrative Review of Technology and Study Results
dc.typeReview
dspace.entity.typePublication
oaire.citation.issue22
oaire.citation.volume24
relation.isOrgUnitOfPublication4b108cd7-08a1-4350-ab3f-20450dec091d
relation.isOrgUnitOfPublication.latestForDiscovery4b108cd7-08a1-4350-ab3f-20450dec091d
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