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Warm Cells, Hot Mitochondria: Achievements and Problems of Ultralocal Thermometry

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dc.contributor.authorKruglov, A. G.
dc.contributor.authorRomshin, A. M.
dc.contributor.authorNikiforova, A. B.
dc.contributor.authorPlotnikova, A.
dc.date.accessioned2024-12-27T12:18:12Z
dc.date.available2024-12-27T12:18:12Z
dc.date.issued2023
dc.description.abstractTemperature is a crucial regulator of the rate and direction of biochemical reactions and cell processes. The recent data indicating the presence of local thermal gradients associated with the sites of high-rate thermogenesis, on the one hand, demonstrate the possibility for the existence of “thermal signaling” in a cell and, on the other, are criticized on the basis of thermodynamic calculations and models. Here, we review the main thermometric techniques and sensors developed for the determination of temperature inside living cells and diverse intracellular compartments. A comparative analysis is conducted of the results obtained using these methods for the cytosol, nucleus, endo-/sarcoplasmic reticulum, and mitochondria, as well as their biological consistency. Special attention is given to the limitations, possible sources of errors and ambiguities of the sensor’s responses. The issue of biological temperature limits in cells and organelles is considered. It is concluded that the elaboration of experimental protocols for ultralocal temperature measurements that take into account both the characteristics of biological systems, as well as the properties and limitations of each type of sensor is of critical importance for the generation of reliable results and further progress in this field.
dc.identifier.citationWarm Cells, Hot Mitochondria: Achievements and Problems of Ultralocal Thermometry / Kruglov, A. G. [et al.] // International Journal of Molecular Sciences. - 2023. - 24. - № 23. - 10.3390/ijms242316955
dc.identifier.doi10.3390/ijms242316955
dc.identifier.urihttps://www.doi.org/10.3390/ijms242316955
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85179336004&origin=resultslist
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/29517
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.subjectTemperature
dc.subjectThermal Analysis
dc.subjectThermodynamics
dc.subjectOrganelle
dc.subjectThermal Tolerance
dc.titleWarm Cells, Hot Mitochondria: Achievements and Problems of Ultralocal Thermometry
dc.typeReview
dspace.entity.typePublication
oaire.citation.issue23
oaire.citation.volume24
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