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Design and characterisation of calcium carbonate microspheres for anticancer drug delivery

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dc.contributor.authorSukhanova, A.
dc.contributor.authorKalenichenko, D.
dc.contributor.authorNifontova, G.
dc.contributor.authorNabiev, I.
dc.contributor.authorКалениченко, Дарья Владимировна
dc.contributor.authorНифонтова, Галина Олеговна
dc.contributor.authorНабиев, Игорь Руфаилович
dc.date.accessioned2024-11-29T23:38:21Z
dc.date.available2024-11-29T23:38:21Z
dc.date.issued2021
dc.description.abstract© 2021 Institute of Physics Publishing. All rights reserved.The development of delivery systems providing prolonged release of antitumor drugs represents one of the challenges in designing and optimization of novel tools for cancer therapy. The employment of spherical inorganic microparticles, in particular, calcium carbonate vaterite microspheres, as microcarriers appears promising because of their porous, matrix structure, biocompatibility, and biodegradability. Here, we summarize the results of the development of the approaches to synthesis of calcium carbonate vaterite microspheres with narrowed size distribution and microencapsulation of low-molecular-weight anticancer drugs, such as doxorubicin hydrochloride into obtained microspheres. Supplementing the reaction mixture with a thickener defines fabrication of homogeneous vaterite microparticles with a spherical shape and an average size of 2 to 3 μm. Synthesised microspheres ensure prolonged release of doxorubicin at physiological pH values and can be used as a delivery system and as a structural component for development of a theranostic platform for tumour treatment and diagnosis.
dc.identifier.citationDesign and characterisation of calcium carbonate microspheres for anticancer drug delivery / Sukhanova, A. [et al.] // Journal of Physics: Conference Series. - 2021. - 2058. - № 1. - 10.1088/1742-6596/2058/1/012009
dc.identifier.doi10.1088/1742-6596/2058/1/012009
dc.identifier.urihttps://www.doi.org/10.1088/1742-6596/2058/1/012009
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85119470314&origin=resultslist
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/25009
dc.relation.ispartofJournal of Physics: Conference Series
dc.titleDesign and characterisation of calcium carbonate microspheres for anticancer drug delivery
dc.typeConference Paper
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume2058
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