Publication:
Differential diagnosis of delusional symptoms in schizophrenia: Brain tractography data

Дата
2023
Авторы
Zakharova, N. V.
Mamedova, G. S.
Bravve, L. V.
Kaydan, M. A.
Kartashov, S. I.
Orlov, V. A.
Ushakov, V. L.
Journal Title
Journal ISSN
Volume Title
Издатель
Научные группы
Организационные подразделения
OrgUnit Logo
Организационная единица
Институт интеллектуальных кибернетических систем
Цель ИИКС и стратегия развития - это подготовка кадров, способных противостоять современным угрозам и вызовам, обладающих знаниями и компетенциями в области кибернетики, информационной и финансовой безопасности для решения задач разработки базового программного обеспечения, повышения защищенности критически важных информационных систем и противодействия отмыванию денег, полученных преступным путем, и финансированию терроризма.
Выпуск журнала
Аннотация
Delusion is an extreme distortion of cognitive processes evaluating reward and prediction, where the damage in structural connectivity between several brain regions responsible for actualization of acquired socioemotional experience and adequate analysis of what is happening serve as a pathomorphological substrate. Referring to the assumption on various neurophysiological developmental mechanisms of two types of delusion, i.e. persecutory and fantastic, we hypothesized that the neural pathways or white matter tracts significantly differ between patients with one of the two types of delusions. Materials and methods: 40 patients suffering from schizophrenia were examined, 25 of them diagnosed with fantastic/paraphrenic delusions and 15 of them having persecutory/interpretative delusions. The control group comprised 42 healthy age- and sex-matched volunteers. Diffusion MR tractography of the brain was performed using 3 T MRI Magnetom Verio, Siemens. Results: statistical decrease in white matter fibers connecting right frontal regions with left motor cortex and certain cerebellar zones was identified in patients with interpretative delusions compared to healthy individuals. Elevated number of white matter fibers was found between the occipital regions and calcarine sulcus of the left hemisphere, and between medial occipitotemporal sulcus of the right hemisphere and right fusiform gyrus when comparing the tracts of patients with fantastic delusions and healthy controls. Conclusions: interpretative delusions are associated with impaired connectivity in the brain regions responsible for adequate monitoring of current reality, whereas fantastic delusions are accompanied by altered connectivity of regions controlling multimodal sensory integration of signals from various analyzers based on long-term memory attributions. © 2022 Elsevier B.V.
Описание
Ключевые слова
Bizarre delusions , Brain white matter , Fantastic delusions , Interpretative delusions , Persecutory delusions , Tractography
Цитирование
Differential diagnosis of delusional symptoms in schizophrenia: Brain tractography data / Zakharova, N.V. [et al.] // Cognitive Systems Research. - 2023. - 77. - P. 217-225. - 10.1016/j.cogsys.2022.10.008
URI
https://www.doi.org/10.1016/j.cogsys.2022.10.008
 https://www.scopus.com/record/display.uri?eid=2-s2.0-85142746254&origin=resultslist
 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000898093400009
 https://openrepository.mephi.ru/handle/123456789/29865
Коллекции
Публикации