Publication:
Influence of magnetic nanoparticle biotransformation on contrasting efficiency and iron metabolism

Простая страница элемента
dc.contributor.authorYaremenko, A. V.
dc.contributor.authorZelepukin, I. V.
dc.contributor.authorIvanov, I. N.
dc.contributor.authorDeyev, S. M.
dc.contributor.authorNikitin, P. I.
dc.contributor.authorДеев, Сергей Михайлович
dc.contributor.authorНикитин, Петр Иванович
dc.date.accessioned2024-12-25T11:20:00Z
dc.date.available2024-12-25T11:20:00Z
dc.date.issued2022
dc.description.abstractMagnetic nanoparticles are widely used in biomedicine for MRI imaging and anemia treatment. The aging of these nanomaterials in vivo may lead to gradual diminishing of their contrast properties and inducing toxicity. Here, we describe observation of the full lifecycle of 40-nm magnetic particles from their injection to the complete degradation in vivo and associated impact on the organism. We found that in 2 h the nanoparticles were eliminated from the bloodstream, but their initial biodistribution changed over time. In 1 week, a major part of the nanoparticles was transferred to the liver and spleen, where they degraded with a half-life of 21 days. MRI and a magnetic spectral approach revealed preservation of contrast in these organs for more than 1 month. The particle degradation led to the increased number of red blood cells and blood hemoglobin level due to released iron without causing any toxicity in tissues. We also observed an increase in gene expression level of Fe-associated proteins such as transferrin, DMT1, and ferroportin in the liver in response to the iron particle degradation. A deeper understanding of the organism response to the particle degradation can bring new directions to the field of MRI contrast agent design. © 2022, The Author(s).
dc.identifier.citationInfluence of magnetic nanoparticle biotransformation on contrasting efficiency and iron metabolism / Yaremenko, A.V. [et al.] // Journal of Nanobiotechnology. - 2022. - 20. - № 1. - 10.1186/s12951-022-01742-w
dc.identifier.doi10.1186/s12951-022-01742-w
dc.identifier.urihttps://www.doi.org/10.1186/s12951-022-01742-w
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85144233801&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000900118300001
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/27733
dc.relation.ispartofJournal of Nanobiotechnology
dc.subjectBiodistribution
dc.subjectIron gene expression
dc.subjectMagnetic nanoparticles
dc.subjectMononuclear phagocyte system
dc.subjectNanoparticle degradation
dc.subjectPharmacokinetics
dc.subjectToxicity
dc.titleInfluence of magnetic nanoparticle biotransformation on contrasting efficiency and iron metabolism
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume20
relation.isAuthorOfPublication66f50b35-0e92-49e0-ad1a-0ac386d858b7
relation.isAuthorOfPublicationba7e8545-c2f2-4ceb-b87c-64517de9a50d
relation.isAuthorOfPublication.latestForDiscovery66f50b35-0e92-49e0-ad1a-0ac386d858b7
relation.isOrgUnitOfPublicationc8407a6f-7272-450d-8d99-032352c76b55
relation.isOrgUnitOfPublication.latestForDiscoveryc8407a6f-7272-450d-8d99-032352c76b55
Файлы
Коллекции
Публикации