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Composite silicon-iron nanoparticles: physical properties and potential application in MRI contrasting

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dc.contributor.authorSobolev, A. V.
dc.contributor.authorKozlyakova, E. S.
dc.contributor.authorVasiliev, A. N.
dc.contributor.authorPerepukhov, A. M.
dc.contributor.authorKargina, Y. V.
dc.contributor.authorKharin, A. Y.
dc.contributor.authorSharonova, N. V.
dc.date.accessioned2024-12-25T14:12:09Z
dc.date.available2024-12-25T14:12:09Z
dc.date.issued2022
dc.description.abstract© 2022, The Author(s), under exclusive licence to Springer Nature B.V.Composite nanoparticles (NPs) based on nanocrystalline silicon (Si) with iron (Fe) content varied from 0.2 to 10 at.% are prepared by an arc-discharge plasma-ablative synthesis and investigated by means of the transmission and scanning electron microscopy, dynamic light scattering, Fourier-transform infrared spectroscopy, Mössbauer spectroscopy, electron paramagnetic resonance, magnetic susceptibility measurements, X-ray diffraction, and nuclear magnetic resonance relaxometry. It is shown that an increase in the Fe content results in an increase in the mean size of Si-Fe NPs from 30 to 400 nm. Iron-enriched agglomerates, which consist of α-FeSi2, α-Fe, and iron oxide, are detected in Si-Fe NPs with Fe content above 2.5 at.%. The magnetization relaxometry reveals a strong shortening of both the longitudinal and transverse proton relaxation times in aqueous suspensions of Si-Fe NPs. The enhanced proton relaxation is explained by the impact of both Fe ions and paramagnetic centers like Si dangling bonds, the contribution of which to the proton relaxation depends on the Fe content. In vitro experiments show that prepared Si-Fe NPs with concentration up to 50 μg/mL are characterized by low cytotoxicity, which slightly increases with increasing iron content. The obtained results demonstrate the possibility of using composite Si-Fe NPs as potential contrast agents for MRI-guided cancer theranostics. Graphical abstract: [Figure not available: see fulltext.]
dc.identifier.citationComposite silicon-iron nanoparticles: physical properties and potential application in MRI contrasting / Sobolev, A.V. [et al.] // Journal of Nanoparticle Research. - 2022. - 24. - № 6. - 10.1007/s11051-022-05497-1
dc.identifier.doi10.1007/s11051-022-05497-1
dc.identifier.urihttps://www.doi.org/10.1007/s11051-022-05497-1
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85131127345&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000805194100001
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/27958
dc.relation.ispartofJournal of Nanoparticle Research
dc.titleComposite silicon-iron nanoparticles: physical properties and potential application in MRI contrasting
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue6
oaire.citation.volume24
relation.isOrgUnitOfPublicationc8407a6f-7272-450d-8d99-032352c76b55
relation.isOrgUnitOfPublication.latestForDiscoveryc8407a6f-7272-450d-8d99-032352c76b55
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