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HER2-Specific Targeted Toxin DARPin-LoPE: Immunogenicity and Antitumor Effect on Intraperitoneal Ovarian Cancer Xenograft Model

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dc.contributor.authorSokolova, E. A.
dc.contributor.authorShilova, O. N.
dc.contributor.authorKiseleva, D. V.
dc.contributor.authorSchulga, A. A.
dc.contributor.authorDeyev, S. M.
dc.contributor.authorДеев, Сергей Михайлович
dc.date.accessioned2024-11-21T09:22:44Z
dc.date.available2024-11-21T09:22:44Z
dc.date.issued2019
dc.description.abstractHigh immunogenicity and systemic toxicity are the main obstacles limiting the clinical use of the therapeutic agents based on Pseudomonas aeruginosa exotoxin A. In this work, we studied the immunogenicity, general toxicity and antitumor effect of the targeted toxin DARPin-LoPE composed of HER2-specific DARPin and a low immunogenic exotoxin A fragment lacking immunodominant human B lymphocyte epitopes. The targeted toxin has been shown to effectively inhibit the growth of HER2-positive human ovarian carcinoma xenografts, while exhibiting low non-specific toxicity and side effects, such as vascular leak syndrome and liver tissue degradation, as well as low immunogenicity, as was shown by specific antibody titer. This represents prospects for its use as an agent for targeted therapy of HER2-positive tumors.
dc.identifier.citationHER2-Specific Targeted Toxin DARPin-LoPE: Immunogenicity and Antitumor Effect on Intraperitoneal Ovarian Cancer Xenograft Model / Sokolova, E.A. [et al.] // International Journal of Molecular Sciences. - 2019. - 20. - № 10. - 10.3390/ijms20102399
dc.identifier.doi10.3390/ijms20102399
dc.identifier.urihttps://www.doi.org/10.3390/ijms20102399
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85066823921&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000471001400030
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/18205
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.titleHER2-Specific Targeted Toxin DARPin-LoPE: Immunogenicity and Antitumor Effect on Intraperitoneal Ovarian Cancer Xenograft Model
dc.typeReview
dspace.entity.typePublication
oaire.citation.issue10
oaire.citation.volume20
relation.isAuthorOfPublication66f50b35-0e92-49e0-ad1a-0ac386d858b7
relation.isAuthorOfPublication.latestForDiscovery66f50b35-0e92-49e0-ad1a-0ac386d858b7
relation.isOrgUnitOfPublicationc8407a6f-7272-450d-8d99-032352c76b55
relation.isOrgUnitOfPublication.latestForDiscoveryc8407a6f-7272-450d-8d99-032352c76b55
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