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Bone-seeking radiopharmaceuticals based on phosphonic acids and 68Ga (review) Остеотропные радиофармацевтические препараты на основе фосфоновых кислот и 68Ga (обзор)

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dc.contributor.authorTishchenko, V. K.
dc.contributor.authorIvanov, S. A.
dc.contributor.authorKaprin, A. D.
dc.contributor.authorPetriev, V. M.
dc.contributor.authorZavestovskaya, I. N.
dc.contributor.authorЗавестовская, Ирина Николаевна
dc.date.accessioned2024-11-25T17:42:30Z
dc.date.available2024-11-25T17:42:30Z
dc.date.issued2020
dc.description.abstract© 2020 National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation. All rights reserved.Bone metastases cause severe bone pain, growing with solid tumor progression, and lead to significant decreasing patients quality of life. Nowadays positron emission tomography (PET) is the most informative method of radionuclide imaging. PET is highly sensitive non-invasive method of visualization of biochemical and molecular processes in the body. It enables to detect tumor lesions when structure changes are not determined or are not specific. Now radiopharmaceuticals based on 18F are available for bone metastases detection by PET. Their major disadvantage is cyclotron-based synthesis of 18F that limits the application of 18F-containing radiopharmaceuticals. During the last 15-17 years the interest in 68Ga has increased drastically around the world. 68Ga is the promising generator-based radionuclide with appropriate nuclear properties (Т1/2=68 min, β+=89%, E+ βmax=1,9 MeV) for radiosynthesis of a broad spectrum of radiopharmaceuticals. In this work nuclear-physical, chemical and biological properties of gallium-68 (68Ga) are presented. The approaches to synthesis of new bone-seeking compounds based on phosphonic acids and 68Ga are highlighted in detail. Thorough data about experimental studies and clinical application of the most promising compounds are also shown in this article.
dc.format.extentС. 102-119
dc.identifier.citationBone-seeking radiopharmaceuticals based on phosphonic acids and 68Ga (review) Остеотропные радиофармацевтические препараты на основе фосфоновых кислот и 68Ga (обзор) / Tishchenko, V.K. [et al.] // Radiation and Risk. - 2020. - 29. - № 1. - P. 102-119. - 10.21870/0131-3878-2020-29-1-102-119
dc.identifier.doi10.21870/0131-3878-2020-29-1-102-119
dc.identifier.urihttps://www.doi.org/10.21870/0131-3878-2020-29-1-102-119
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85082737463&origin=resultslist
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/20514
dc.relation.ispartofRadiation and Risk
dc.titleBone-seeking radiopharmaceuticals based on phosphonic acids and 68Ga (review) Остеотропные радиофармацевтические препараты на основе фосфоновых кислот и 68Ga (обзор)
dc.typeReview
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume29
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relation.isAuthorOfPublication.latestForDiscovery1a1d2a9c-068f-48c6-b18a-7da3ce75cf7a
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relation.isOrgUnitOfPublication.latestForDiscoveryc8407a6f-7272-450d-8d99-032352c76b55
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