Publication: The biodistribution of a new bone-seeking agent based on pentaphosphonic acid and gallium-68 in tumor-bearing rats
Дата
2019
Авторы
Tishchenko, V. K.
Mikhailovskaya, A. A.
Smoryzanova, O. A.
Petriev, V. M.
Postnov, A. A.
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© 2019 Published under licence by IOP Publishing Ltd. Many tumors are associated with the occurrence of bone metastases, so skeletal imaging, especially by positron emission tomography (PET), is a major problem in clinical nuclear medicine. Gallium-68 ( 68 Ga) is an interesting radionuclide for PET because of its appropriate radiophysical properties. Phosphonates are known to be selectively accumulated in bone tissue, so they can be ideal carriers of radionuclides. The present study was devoted to development of a new compound based on pentaphosphonic acid labeled with 68 Ga ( 68 Ga-PPA) as a potential bone imaging agent for PET applications and evaluation of its biodistribution in Wistar rats with subcutaneously transplanted cholangioma RS-1. Biodistribution studies of 68 Ga-PPA demonstrated rapid and selective bone accumulation and low uptake in any of the major organs and tissues. A total uptake of 68 Ga-PPA in skeleton reached 31.17±2.84 %ID and retained at the same level until the end of the study. However, the amount of 68 Ga-PPA in bone tissue was slightly lower as compared with free 68 Ga 3 +, but lower level of 68 Ga-PPA in blood made it more suitable for diagnostic purposes. In conclusion, 68 Ga-PPA may serve a promising agent in nuclear medicine for bone tissue PET imaging.
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The biodistribution of a new bone-seeking agent based on pentaphosphonic acid and gallium-68 in tumor-bearing rats / Tishchenko, V.K. [et al.] // Journal of Physics: Conference Series. - 2019. - 1189. - № 1. - 10.1088/1742-6596/1189/1/012042