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Laser-synthesized TiN nanoparticles as promising plasmonic alternative for biomedical applications

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dc.contributor.authorPopov, Anton A.
dc.contributor.authorTselikov, Gleb
dc.contributor.authorDumas, Noe
dc.contributor.authorBerard, Charlotte
dc.contributor.authorKabashin, Andrei V.
dc.contributor.authorКабашин, Андрей Викторович
dc.date.accessioned2024-11-20T09:27:32Z
dc.date.available2024-11-20T09:27:32Z
dc.date.issued2019
dc.description.abstractExhibiting a red-shifted absorption/scattering feature compared to conventional plasmonic metals, titanium nitride nanoparticles (TiN NPs) look as very promising candidates for biomedical applications, but these applications are still underexplored despite the presence of extensive data for conventional plasmonic counterparts. Here, we report the fabrication of ultrapure, size-tunable TiN NPs by methods of femtosecond laser ablation in liquids and their biological testing. We show that TiN NPs demonstrate strong and broad plasmonic peak around 640-700 nm with a significant tail over 800 nm even for small NPs sizes (< 7 nm). In vitro tests of laser-synthesized TiN NPs on cellular models evidence their low cytotoxicity and excellent cell uptake. We finally demonstrate a strong photothermal therapy effect on U87-MG cancer cell cultures using TiN NPs as sensitizers of local hyperthermia under near-infrared laser excitation. Based on absorption band in the region of relative tissue transparency and acceptable biocompatibility, laser-synthesized TiN NPs promise the advancement of biomedical modalities employing plasmonic effects, including absorption/scattering contrast imaging, photothermal therapy, photoacoustic imaging and SERS.
dc.identifier.citationLaser-synthesized TiN nanoparticles as promising plasmonic alternative for biomedical applications / Popov, AntonA [et al.] // Scientific Reports. - 2019. - 9. - 10.1038/s41598-018-37519-1
dc.identifier.doi10.1038/s41598-018-37519-1
dc.identifier.urihttps://www.doi.org/10.1038/s41598-018-37519-1
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85061055299&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000457616300083
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/16521
dc.relation.ispartofScientific Reports
dc.titleLaser-synthesized TiN nanoparticles as promising plasmonic alternative for biomedical applications
dc.typeArticle
dspace.entity.typePublication
oaire.citation.volume9
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relation.isAuthorOfPublication.latestForDiscoveryb79a080b-900d-4655-ba2e-53fd552b3a15
relation.isOrgUnitOfPublicationc8407a6f-7272-450d-8d99-032352c76b55
relation.isOrgUnitOfPublication.latestForDiscoveryc8407a6f-7272-450d-8d99-032352c76b55
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