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Sublingual administration of 5-aminolevulinic acid for laser-induced photodiagnostics and photodynamic therapy of oral cavity and larynx cancers

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dc.contributor.authorShiryaev, A. A.
dc.contributor.authorRusakov, M. A.
dc.contributor.authorSimonova, M. S.
dc.contributor.authorSamoylova, S. I.
dc.contributor.authorAlekseeva, P. M.
dc.contributor.authorEfendiev, K. T.
dc.contributor.authorLoschenov, V. B.
dc.contributor.authorЭфендиев, Канамат Темботович
dc.contributor.authorЛощенов, Виктор Борисович
dc.date.accessioned2024-11-29T13:05:55Z
dc.date.available2024-11-29T13:05:55Z
dc.date.issued2021
dc.description.abstract© 2021 Elsevier B.V.Background: The study aimed to develop a method for sublingual administration of 5-aminolevulinic acid to patients and evaluate its effectiveness in fluorescence diagnostics and photodynamic therapy of neoplasms of the oral cavity and larynx. Methods: The boundaries of the neoplasms were established by the video-fluorescence diagnostics and clarified using spectral-fluorescent diagnosis before and after photodynamic therapy. Results: The fluorescence diagnostics demonstrated a high accumulation of protoporphyrin IX, induced by sublingual administration of 5-aminolevulinic acid to patients before the photodynamic therapy and photobleaching of protoporphyrin IX in pathologically altered tissues after the photodynamic therapy. Glucose contained in the sublingual dose supports active transport of 5-ALA into the cells. It increases the PpIX accumulation in the cells, therefore improving the PD and PDT efficacy. Conclusion: The study and the initially obtained results demonstrated the possibility and effectiveness of laser-induced photodiagnostics and photodynamic therapy with sublingual administration of 5-ALA to patients with premalignant lesions of the oral cavity and larynx. It can eliminate the threat of the transformation of these diseases into malignant tumors and prevent the need for surgical treatment.
dc.identifier.citationSublingual administration of 5-aminolevulinic acid for laser-induced photodiagnostics and photodynamic therapy of oral cavity and larynx cancers / Shiryaev, A.A. [et al.] // Photodiagnosis and Photodynamic Therapy. - 2021. - 34. - 10.1016/j.pdpdt.2021.102289
dc.identifier.doi10.1016/j.pdpdt.2021.102289
dc.identifier.urihttps://www.doi.org/10.1016/j.pdpdt.2021.102289
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85104148543&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000664963700003
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/23885
dc.relation.ispartofPhotodiagnosis and Photodynamic Therapy
dc.titleSublingual administration of 5-aminolevulinic acid for laser-induced photodiagnostics and photodynamic therapy of oral cavity and larynx cancers
dc.typeArticle
dspace.entity.typePublication
oaire.citation.volume34
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