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Prognostic Value of Serum Transferrin Analysis in Patients with Ovarian Cancer and Cancer-Related Functional Iron Deficiency: A Retrospective Case–Control Study

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dc.contributor.authorIvanova, T. I.
dc.contributor.authorKlabukov, I. D.
dc.contributor.authorKrikunova,L. I.
dc.contributor.authorPoluektova, M. V.
dc.date.accessioned2024-12-25T11:39:46Z
dc.date.available2024-12-25T11:39:46Z
dc.date.issued2022
dc.description.abstract(1) Background: There are no reliable and widely available markers of functional iron deficiency (FID) in cancer. The aim of the study was to evaluate the role of transferrin (Tf) as a marker of cancer of the ovary (CrO) and related FID. (2) Methods: The study groups consisted of 118 patients with CrO and 69 control females. Blood serum iron status was determined on a Beckman Coulter AU (USA) analyzer. Tf quantification was performed by immunoturbidimetry. The relative contents of apo- and holo-Tf (iron-free and iron-saturated Tf, respectively) were determined in eight patients and a control female by immunochromatographic analysis based on the use of monoclonal single-domain antibodies (nanobodies). (3) Results: Four groups of patients with different iron statuses were selected according to ferritin and transferrin saturation values: absolute iron deficiency (AID) (n = 42), FID (n = 70), iron overload (n = 4), normal iron status (n = 2). The groups differed significantly in Tf values (p < 0.0001). Lower values of Tf were associated with FID. Furthermore, FID is already found in the initial stages of CrO (26%). Immunosorbents based on nanobodies revealed the accumulation of apo-Tf and the decrease in holo-Tf in patients with CrO. (4) Conclusions: Tf may be a promising tool for diagnosing both CrO and associated FID.
dc.identifier.citationPrognostic Value of Serum Transferrin Analysis in Patients with Ovarian Cancer and Cancer-Related Functional Iron Deficiency: A Retrospective Case–Control Study / Ivanova, T. I. [et al.] // Journal of Clinical Medicine. - 2022. - 11. - № 24. - 10.3390/jcm11247377
dc.identifier.doi10.3390/jcm11247377
dc.identifier.urihttps://www.doi.org/10.3390/jcm11247377
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85144719681&origin=resultslist
dc.identifier.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000902517800001
dc.identifier.urihttps://openrepository.mephi.ru/handle/123456789/27766
dc.relation.ispartofJournal of Clinical Medicine
dc.titlePrognostic Value of Serum Transferrin Analysis in Patients with Ovarian Cancer and Cancer-Related Functional Iron Deficiency: A Retrospective Case–Control Study
dc.typeArticle
dspace.entity.typePublication
oaire.citation.issue24
oaire.citation.volume11
relation.isOrgUnitOfPublication4b108cd7-08a1-4350-ab3f-20450dec091d
relation.isOrgUnitOfPublication.latestForDiscovery4b108cd7-08a1-4350-ab3f-20450dec091d
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